This study is looking at an oral medication called Pregnenolone for adults who have both cannabis use disorder and major depressive disorder. Pregnenolone is a neurosteroid, which means it's a natural chemical in the brain that might help reduce the effects of cannabis and improve mood. We want to see how the body handles Pregnenolone, if it's safe, and if people can tolerate taking it. To join, you need to be between 18 and 50 years old, have both conditions, use cannabis at least 4 days a week, and be willing to reduce your cannabis use. The main goal is to see how many days you use cannabis over 12 weeks.

Study design

This is an interventional study with a planned enrollment of 20 participants. It is the first part of a larger research program.

What's involved

You would take Pregnenolone orally for about 12 weeks. The study will also look at how your body processes the medication.

Compensation

Not stated in the trial record.

Follow-up

The primary outcome, percent days of cannabis use, is measured at 12 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.