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Precision Management of Urinary Tract Symptoms in Older Women

This study is looking for women aged 65 or older who have a history of recurrent urinary tract infections (UTIs). The goal is to find the best way to treat UTI symptoms in older women. You would be randomly assigned to one of three treatment groups: receiving antibiotics right away (nitrofurantoin, trimethoprim/sulfamethoxazole, fosfomycin, ciprofloxacin, or cephalexin), receiving antibiotics based on a urine test, or receiving antibiotics based on a urine culture. Researchers will then see if your symptoms improve after 14 days. This study aims to help doctors decide when antibiotics are truly needed for UTIs in older women, improving care and reducing unnecessary antibiotic use. Enrollment is planned for 90 participants, but the current status is unclear.

Study design
This is a randomized pilot study comparing three different treatment approaches for UTI symptoms. It plans to enroll 90 women.
What's involved
You would be followed for a total of 28 days after being enrolled and randomized.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 28 days after randomization, with clinical success measured at 14 days.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07686055

Precision Management of Urinary Tract Symptoms in Older Women

Not Yet Recruiting
PHASE3Ages 65+InterventionalTreatment
Megan Bradley
~90 participants
Updated 2026-07-07 on ClinicalTrials.gov
What's tested:Antibiotics

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Clinical Success at 14 Days
Measured over 14 days

Conditions

Urinary Tract Infection (Diagnosis)

Explore related trials

Urinary Tract Infection

Where it's being run

1 sites across 1 states
Pennsylvania1

Study leadership

  • Megan Bradley, MD, MSc · PRINCIPAL_INVESTIGATOR · University of Pittsburgh

Who to contact

Megan S Bradley, MD MSc
[email protected]
412-641-7850
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Female biologic Sex
Age ≥65 years old
History of recurrent UTI per patient report of greater than 2 UTIs in the last 6 months or 3 UTIs in the last year
Patient reported UTI defined as:
Dysuria, increased urinary urgency/frequency and/or suprapubic pain

Exclusion

Male biologic sex
Age \<65 years old
History of augmentation cystoplasty or cystectomy
Currently performing clean intermittent self-catheterization
Current indwelling foley catheter
Urinary tract instrumentation (i.e., cystourethroscopy, foley catheter placement) in the last 30 days
Undergoing treatment for malignancy
History of either confirmed or patient reported pyelonephritis and/or urosepsis
Cirrhosis and/or end stage liver disease
Chronic kidney disease with most recent estimated glomerular filtration rate \<50 ml/min
Dementia and/or currently reside in skilled nursing facility
Current high-dose chronic steroids (\>20mg/day of prednisone)
Previous solid organ transplant
Provider concern for pyelonephritis and/or sepsis (i.e., fevers)
Unwilling or unable to comply with study procedures (including ability to complete electronic questionnaires)

What this trial measures

  • Clinical Success at 14 Days14 days

    Score of \<1 on question 1 (urinary burning),3 (urinary urgency) and 5 (urinary frequency) on Urinary Tract Infection Symptom Assessment at day 14. A lower scale correlates with better symptoms with 0 being no symptoms and 1 being "little" symptoms.