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Study on IQOS Heated Tobacco Products for Adults Who Smoke

This study is looking at how adults who smoke cigarettes experience IQOS heated tobacco products compared to their usual cigarettes. Researchers want to understand how appealing IQOS is and what sensory effects (like taste or feel) it has. You would use IQOS HeatSticks, matched to your usual cigarette flavor, and also smoke your usual brand of cigarettes during study visits. The study aims to see how these products are used and how they affect your senses. This study is for adults aged 21-65 who smoke at least five days a week. The study plans to enroll 30 participants, but its current recruitment status is unclear.

Study design
This is an interventional study with 30 participants, randomized into two groups. Each group will try both IQOS HeatSticks and their usual brand of cigarettes.
What's involved
You would attend two laboratory visits, at least 48 hours apart. During each visit, you would use either IQOS HeatSticks or smoke your usual brand of cigarettes for 60 minutes. You also need to abstain from nicotine for 12 hours before each visit and bring your usual brand of cigarettes.
Compensation
Not stated in the trial record.
Follow-up
The primary measurements are taken at 5, 35, and 60 minutes during the product use sessions.

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NCT07688304

The Abuse Liability of IQOS Heated Tobacco Products Among Adults Who Smoke

Not Yet Recruiting
NAAges 21–65Interventional
Ohio State University Comprehensive Cancer Center
~30 participants
Updated 2026-07-07 on ClinicalTrials.gov
What's tested:Smoking Behavioral Research (IQOS)Smoking Behavioral Research (UBC)

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Product Appeal
Measured over Minute 5 of product use session, Minute 35 of product use session, Minute 60 of product use session
+9 more outcomes measured

Conditions

Tobacco

Explore related trials

Tobacco

Where it's being run

1 sites across 1 states
Ohio1

Study leadership

  • Alayna P Tackett, PhD · PRINCIPAL_INVESTIGATOR · Ohio State University Comprehensive Cancer Center

Who to contact

The Ohio State University Comprehensive Cancer Center
[email protected]
800-293-5066
Email the study team

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Eligibility criteria

Inclusion

Adults 21-65 years
Adults who smoke (defined as ≥ 5 days weekly use of either menthol or non-menthol cigarettes over the past 3 months)
Willing to provide informed consent and abstain from using nicotine products 12 hours before each visit
Willing to bring UBC to each study visit
Read, write and speak English

Exclusion

Current use of other non-combustible nicotine products (e.g., electronic \[e\]-cigarettes, HTPs; \[defined as ≥ 5 days weekly use in the past 30 days\])
Planning to quit nicotine use and/or use of any smoking cessation medication in the past 30 days
Current diagnosis of any lung diseases (e.g., asthma, cystic fibrosis, or chronic obstructive pulmonary disease)
Self-reported unstable or significant psychiatric conditions (past/stable conditions will be allowed)
History of cardiac event or distress within the past 3 months
Deaf, hard of hearing, or have a severe motor disability
Are currently pregnant, planning to become pregnant, or breastfeeding (urine pregnancy test will be completed at each visit throughout the study)

What this trial measures

  • Product AppealMinute 5 of product use session, Minute 35 of product use session, Minute 60 of product use session

    Participants will complete the Appeal and Sensory Quality questionnaire. This questionnaire will ask participants to rate each study product for appeal characteristics such as liking, willingness to use again, flavor intensity, pleasantness of taste, etc. on a scale of 0 (not at all) - 100 (extremely). Higher scores indicate greater liking, willingness to use again, flavor intensity, etc.

  • Product Sensory AttributesMinute 5 of product use session, Minute 35 of product use session, Minute 60 of product use session

    Participants will rate sensory attributes using the Appeal and Sensory Quality questionnaire. This questionnaire will ask participants to rate each study product for sensory attributes such as harshness, coolness, sweetness, etc. on a scale of 0 (not at all) - 100 (extremely). Higher scores indicate greater harshness, coolness, sweetness, etc.

  • Economic demand breakpointMinute 60 of product use session

    The price point at which a participant is no longer willing to pay for a stick of the study product will be determined by using a cigarette purchase task questionnaire.

  • Satisfaction and psychological rewardMinute 5 of product use session, Minute 35 of product use session, Minute 60 of product use session

    Satisfaction and psychological reward of study product use will be measured by the Modified Cigarette Evaluation Questionnaire (mCEQ). The mCEQ asks questions relating to satisfaction of using the study product on a scale from 0 (Not at all) - 6 (Extremely).

  • Abuse Liability Via Puff Topography - Total Smoking TimeMinute 60 of product use session

    Will be measured with a topography device that records frequency, duration, and flow rate of cigarette puffs. These measures are combined to inform overall cigarette puff behavior.

  • Abuse Liability Via Puff Topography - Average Puff DurationMinute 60 of product use session

    Will be measured with a topography device that records frequency, duration, and flow rate of cigarette puffs. These measures are combined to inform overall cigarette puff behavior.

  • Abuse Liability Via Puff Topography - Average Flow RateMinute 60 of product use session

    Will be measured with a topography device that records frequency, duration, and flow rate of cigarette puffs. These measures are combined to inform overall cigarette puff behavior.

  • Abuse Liability Via Puff Topography - Average Inter-Puff IntervalMinute 60 of product use session

    Will be measured with a topography device that records frequency, duration, and flow rate of cigarette puffs. These measures are combined to inform overall cigarette puff behavior.

  • Abuse Liability Via Puff Topography - Average Puff VolumeMinute 60 of product use session

    Will be measured with a topography device that records frequency, duration, and flow rate of cigarette puffs. These measures are combined to inform overall cigarette puff behavior.

  • Craving/withdrawalMinute 0 before product use session, Minute 5 of product use session, Minute 35 of product use session, minute 60 of product use session

    Nicotine withdrawal and craving symptoms will be measured using the Minnesota Nicotine Withdrawal Scale (MNWS)