Photoimmunotherapy for Locally Advanced Pancreatic Cancer

This study is testing a new treatment called ASP-1929 photoimmunotherapy for people with locally advanced or metastatic pancreatic cancer that cannot be removed by surgery. This treatment combines an antibody (a protein that targets specific cells) with a special dye. About 24 hours before planned surgery, you would receive ASP-1929 through an IV. The study aims to see how safe ASP-1929 is (looking at side effects) and how well it prevents the cancer from growing for at least six months. This is an early-stage study, and it's currently unclear if it's recruiting new participants.

Study design
This is an open-label Phase II study, meaning both you and your doctors will know which treatment you are receiving. It plans to enroll 30 participants.
What's involved
You would receive ASP-1929 intravenously (IV) about 24 hours before a planned surgical exploration. This treatment will be given 4 to 10 weeks after your last chemotherapy and radiation.
Compensation
Not stated in the trial record.
Follow-up
Your health will be monitored for treatment-related side effects for up to 28 days after surgery, and for cancer progression for at least 6 months after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07698613

EGFR Targeted Photoimmunotherapy With ASP-1929 for Locally Advanced Pancreatic Cancer

Not Yet Recruiting
PHASE1Ages 18+InterventionalTreatment
Brown University
~30 participants
Updated 2026-07-13 on ClinicalTrials.gov
What's tested:ASP-1929 photoimmunotherapy

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Incidence of treatment related toxicities grade ≥3
Measured over From start of treatment to 28 days post surgery
+1 more outcome measured
Pancreatic Cancer Patients Diagnosed With Locally Advanced or Metastatic Pancreatic Cancer Not Amenable to Curative Surgical Resection
Pancreatic Cancer Borderline
Pancreatic Cancer Resectable

NCT07698613

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Rhode Island and the Miriam Hospitals (Brown University Health)

    Providence, Rhode Islandno site contact published

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

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  • Incidence of treatment related toxicities grade ≥3From start of treatment to 28 days post surgery

    Part 1 \| Safert: The primary endpoint is grade 3 or higher ASP-1929 photoimmunotherapy treatment related toxicity within 28 days of surgery.

  • Number of Participants Reaching 6 Months Progression Free SurvivalFrom start of treatment to 6 months post surgery.

    Part 2 (expansion cohort for efficacy): The primary endpoint of this cohort is 6-month progression free survival. RECIST version 1.1 will be used to assess for response/progression