This study is looking at whether monosodium glutamate (MSG), a common food flavor enhancer, affects the levels of a substance called imidazole propionate (ImP) in your blood. ImP is made by gut bacteria and has been linked to blood sugar control issues. Researchers want to see if taking MSG along with L-histidine (a dietary supplement) increases blood ImP levels compared to taking a salt placebo with L-histidine. They will also track how ImP levels change over time. You can join if you are a healthy adult, aged 18 or older, and have not used antibiotics recently. You cannot participate if you have diabetes, inflammatory bowel disease, an MSG allergy, or are pregnant or breastfeeding. The study plans to enroll 18 healthy volunteers.

Study design

This is an interventional study involving 18 healthy adult volunteers. Participants will receive L-histidine along with either monosodium glutamate or sodium chloride (salt) placebo.

What's involved

Participants will take L-histidine, 4 g/day, and either monosodium glutamate, 3 g/day, or sodium chloride, 940 mg/day, for 7 days during each treatment period.

Compensation

Not stated in the trial record.

Follow-up

Blood imidazole propionate concentration will be measured at Day 7 of each treatment period.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.