Comparing Procedures for Chronic Rhinitis

This study is comparing three different in-office procedures for adults with chronic rhinitis (non-allergic rhinitis), a condition causing ongoing nasal inflammation without allergies or infection. The procedures being tested are RhinAer, Neuromark (both use heat), and ClariFix (uses freezing). All are performed under local anesthesia. Researchers want to find out which procedure best reduces your nasal symptoms and improves your quality of life. They will measure your symptoms and quality of life at the start, and then at 1, 3, and 6 months after the procedure. The study aims to enroll 50 participants, but its current status is unclear.

Study design
This is an interventional study that will randomly assign 50 adult participants to one of three treatment groups: RhinAer, Neuromark, or ClariFix.
What's involved
You would undergo one of the three procedures. Your nasal symptoms and quality of life will be measured at the start, and then at 1, 3, and 6 months after the procedure.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 6 months after their procedure to assess symptom reduction and quality of life.

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NCT07706595

A Randomized Controlled Trial Comparing Posterior Nasal Nerve Ablation Procedures for Chronic Rhinitis

Enrolling by Invitation
NAAges 18+InterventionalTreatment
University of California, San Diego
~50 participants
Updated 2026-07-16 on ClinicalTrials.gov
What's tested:RhinAerNeuromarkClarifix

At a glance

Recruiting sites
0 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Sino-Nasal Outcome Test-22 (SNOT-22)
Measured over SNOT-22 will be administered at baseline and at 1, 3, and 6 months post-procedure.
+1 more outcome measured
Chronic Rhinitis
Non-allergic Rhinitis
2 sites across 1 states
California2

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age 18 years or older
Diagnosis of chronic rhinitis (non-allergic rhinitis)
  • Sino-Nasal Outcome Test-22 (SNOT-22)SNOT-22 will be administered at baseline and at 1, 3, and 6 months post-procedure.

    SNOT-22 is a validated 22-item patient-reported outcome measure assessing sinonasal-specific quality of life across domains including nasal symptoms (nasal blockage, rhinorrhea, loss of smell/taste), ear and facial symptoms (ear pain, facial pressure), sleep dysfunction (difficulty falling asleep, waking up tired), and psychological and functional impairment (reduced productivity, fatigue, sadness).

  • Total Nasal Symptom Score (TNSS)TNSS will be administered at baseline and at 1, 3, and 6 months post-procedure.

    TNSS is a validated 4-item patient-reported scoring instrument measuring severity of rhinorrhea, nasal congestion, nasal itching, and sneezing.