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Intraoperative Neuromonitoring for Sacral Surgery

This study is looking at how well monitoring your sacral reflexes (nerve responses in the lower spine) during surgery (intraoperative neuromonitoring) can predict your function after surgery. This is for patients having surgery to remove part of their lower spine (sacrectomy) due to pelvic bone cancer, or those having other spinal procedures without sacral nerve involvement. These surgeries can sometimes affect nerves that control leg movement, and bowel, bladder, and sexual function. By monitoring these reflexes during surgery, doctors hope to get real-time information about nerve function. The main goal is to see if we can reliably get and understand these reflex responses during surgery. You would undergo standard surgery and intraoperative nerve monitoring, and complete surveys. This study is for adults aged 18 and older who are having surgery at City of... and are willing to complete study questionnaires.

Study design
This is an interventional study with a planned enrollment of 50 participants. It is not specified if it is randomized or blinded.
What's involved
You would undergo intraoperative nerve monitoring during your surgery and complete postoperative patient-reported outcome assessments. You would also complete study questionnaires and comply with all study procedures.
Compensation
Not stated in the trial record.
Follow-up
Your bulbocavernosus reflex (BCR) and external urethral sphincter (EUS) reflex responses will be measured from baseline up to 1 year after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07707024

Intraoperative Neuromonitoring of Sacral Reflexes to Predict Post Operative Function in Patients Undergoing Sacrectomy for Pelvic Bone Malignancy or Patients Undergoing Spinal Procedures Without Sacral Root Involvement

Not Yet Recruiting
NAAges 18+InterventionalDiagnostic
City of Hope Medical Center
~50 participants
Updated 2026-07-16 on ClinicalTrials.gov
What's tested:Intraoperative Nerve MonitoringSurgical ProcedureSurvey Administration

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Reproducible and interpretable bulbocavernosus reflex (BCR) and external urethral sphincter (EUS) reflex responses (feasibility)
Measured over From baseline, Up to 1 year

Conditions

Bone Neoplasm
Metastatic Malignant Neoplasm in the Bone

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Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • City of Hope Medical Center

    Duarte, Californiastudy coordinator listed

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Alana M Munger · PRINCIPAL_INVESTIGATOR · City of Hope Medical Center

Who to contact

Alana M. Munger
[email protected]
808-384-0975
Email the study team

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Eligibility criteria

Inclusion

Documented informed consent of the participant and/or legally authorized representative.
Assent, when appropriate, will be obtained per institutional guidelines
Age: ≥ 18 years
Ability to complete study questionnaires
Willingness to comply with all study procedures, including postoperative patient-reported outcome (PRO) assessments
Undergoing surgery at City of Hope involving either:
Complete or partial sacrectomy for primary or metastatic bone tumors, or
Thoracolumbar intervention in which the sacral roots are not exposed or manipulated (reference cohort)

Exclusion

Prior sacrectomy or prior surgery resulting in complete sacral nerve transection
For thoracolumbar cohort patients, prior diagnosis or patient report of bowel or bladder dysfunction
Cognitive or psychiatric conditions preventing reliable completion of PRO instruments

What this trial measures

  • Reproducible and interpretable bulbocavernosus reflex (BCR) and external urethral sphincter (EUS) reflex responses (feasibility)From baseline, Up to 1 year

    Reproducible is defined as the ability to elicit a reflex response on repeated stimulation with consistent waveform presence and morphology at a given timepoint. Interpretable is defined as a recorded reflex response that is distinguishable from background noise and artifact and permits determination of response presence or absence and measurement of latency and amplitude. A two-sided 95% Clopper-Pearson confidence interval will be provided as a measure of precision.