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Observational Study of Upright Proton Therapy

This study, called UPRIGHT-PRO, is looking at whether cancer patients can safely receive standard proton therapy while positioned upright. Proton therapy is a type of radiation treatment. The upright treatment system used in this study has been approved by the FDA. The study will observe how patients are treated, the doses they receive, and their outcomes. You may be able to join if you are a child or adult with cancer and your doctor recommends proton therapy. The main goal is to see if upright proton therapy is practical and feasible. The study status is currently unclear, and it plans to include 450 participants.

Study design
This is an observational study that plans to enroll 450 participants. It is not a randomized trial, meaning treatments are not assigned by the study.
What's involved
Participants will receive standard-of-care proton therapy at Stanford. The study will observe treatment methods, doses, and outcomes.
Compensation
Not stated in the trial record.
Follow-up
Feasibility of upright proton therapy will be measured at the end of proton therapy (3 months).

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07708636

UPRIGHT-PRO: Prospective Development Study of Upright Proton Therapy

Not Yet Recruiting
Not specifiedAll AgesObservational
Stanford University
~450 participants
Updated 2026-07-16 on ClinicalTrials.gov
What's tested:Standard-of-Care Proton Therapy

At a glance

Recruiting sites
0 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Feasibility of upright proton therapy
Measured over End of proton therapy (3 months)

Conditions

Proton Therapy

Explore related trials

Malignant Neoplasm

Where it's being run

2 sites across 1 states
California2

Study leadership

  • Yuan J Rao, MD · PRINCIPAL_INVESTIGATOR · Stanford University

Who to contact

Aryan Dwivedi
[email protected]
[email protected]
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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Any cancer patient (children and adults) recommended for proton therapy.
Participation in other clinical trials is allowed (including randomized trials of protons versus other treatments)

What this trial measures

  • Feasibility of upright proton therapyEnd of proton therapy (3 months)

    Feasibility is defined by the proportion of evaluable patients who complete a technically successful course of upright proton therapy. Technically successful course of upright proton therapy is defined as ≥80% of prescribed proton fractions delivered with upright proton therapy. Feasible if ≥70% of evaluable cases meet technically successful criterion.