Lidocaine Ointment for Reducing Coughing After Anesthesia

This study is testing if applying 5% lidocaine ointment to an endotracheal tube (breathing tube) before surgery can reduce coughing or bucking (a forceful cough) when you wake up from general anesthesia. The study compares this to using a standard water-based lubricant. We are looking for adults aged 18 to 90 who are having surgery that requires a breathing tube. The main goal is to see if the lidocaine ointment lowers the number of people who cough or buck as they are waking up and the breathing tube is removed. This study is currently unclear on its recruitment status and aims to enroll 212 participants.

Study design
This is a randomized, double-blind study with two groups, involving 212 participants. You would be randomly assigned to receive either the lidocaine ointment or the standard lubricant.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The main outcome of coughing or bucking will be assessed from when you start waking up until the breathing tube is removed, which is typically about 5-30 minutes after the anesthetic is reduced.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07709390

ENDOTRACHEAL Tube LIDOCAINE

Not Yet Recruiting
EARLY_PHASE1Ages 18–90InterventionalPrevention
Ohio State University
~212 participants
Updated 2026-07-16 on ClinicalTrials.gov
What's tested:5% Lidocaine OintmentWater-Based Lubricant

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Incidence of Coughing or Bucking During Emergence from General Anesthesia
Measured over From initiation of emergence from anesthesia until endotracheal tube removal, assessed during the extubation period (approximately 5-30 minutes after anesthetic reduction).
Emergency Coughing
1 sites across 1 states
Ohio1

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  • Incidence of Coughing or Bucking During Emergence from General AnesthesiaFrom initiation of emergence from anesthesia until endotracheal tube removal, assessed during the extubation period (approximately 5-30 minutes after anesthetic reduction).

    The incidence of coughing or bucking occurring during emergence from anesthesia, defined as any cough or bucking movement from the time anesthetic agents are reduced for extubation until removal of the endotracheal tube. The outcome will be assessed by direct observation and recorded as the presence or absence of coughing/bucking and the number of bucking episodes using a standardized assessment.