Sustained Release Oral Formulation for Parkinson's Disease

This study is testing a new way to deliver medications for Parkinson's disease, called LD/CD (levodopa/carbidopa), using special sachets placed in your mouth. We want to see how your body absorbs these medications from three different formulations (Formulation A, B, and C). This study is looking for 32 healthy volunteers, aged 18 to 65, who don't take regular medications. The main goal is to measure the levels of CD and LD in your blood at 15 and 30 minutes after you take the medication. The current recruitment status is unclear.

Study design
This is a randomized, double-blind (meaning you won't know which dose you're getting), single-dose crossover study involving healthy volunteers.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your blood levels of CD and LD will be measured at 15 and 30 minutes after taking the medication.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07709741

Sustained Release Oral Formulation For Treatment Of Parkinsons Disease

Not Yet Recruiting
PHASE1Ages 18–65Interventional
University of Minnesota
~32 participants
Updated 2026-08-10 on ClinicalTrials.gov
What's tested:Formulation AFormulation BFormulation C

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Blood CD Level - Minute 15
Measured over Minute 15 after administration
+21 more outcomes measured
Healthy Volunteers

NCT07709741

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Minnesota

    Minneapolis, Minnesotastudy coordinator listed

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Khalaf Bushara, MD, FRCP · PRINCIPAL_INVESTIGATOR · University of Minnesota

Opens a ready-to-send draft in your own email app — review before sending.

Want this trial checked against your situation?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Adult healthy male or female
Age 18 to 65 years
Willingness and ability to complete study procedures

Exclusion

medical conditions that require taking medications regularly.
  • Blood CD Level - Minute 15Minute 15 after administration

    Measured in \[ng/mL\]

  • Blood LD Level - Minute 15Minute 15 after administration

    Measured in \[ng/mL\]

  • Blood CD Level - Minute 30Minute 30 after administration

    Measured in \[ng/mL\]

  • Blood LD Level - Minute 30Minute 30 after administration

    Measured in \[ng/mL\]

  • Blood CD Level - Minute 45Minute 45 after administration

    Measured in \[ng/mL\]

  • Blood LD Level - Minute 45Minute 45 after administration

    Measured in \[ng/mL\]

  • Blood CD Level - Hour 1One hour after administration

    Measured in \[ng/mL\]

  • Blood LD Level - Hour 1One hour after administration

    Measured in \[ng/mL\]

  • Blood CD Level - Hour 2Two hours after administration

    Measured in \[ng/mL\]

  • Blood LD Level - Hour 2Two hours after administration

    Measured in \[ng/mL\]

  • Blood CD Level - Hour 3Three hours after administration

    Measured in \[ng/mL\]

  • Blood LD Level - Hour 3Three hours after administration

    Measured in \[ng/mL\]

  • Blood CD Level - Hour 4Four hours after administration

    Measured in \[ng/mL\]

  • Blood LD Level - Hour 4Four hours after administration

    Measured in \[ng/mL\]

  • Blood CD Level - Hour 5Five hours after administration

    Measured in \[ng/mL\]

  • Blood LD Level - Hour 5Five hours after administration

    Measured in \[ng/mL\]

  • Blood CD Level - Hour 6Six hours after administration

    Measured in \[ng/mL\]

  • Blood LD Level - Hour 6Six hours after administration

    Measured in \[ng/mL\]

  • Blood CD Level - Hour 7Seven hours after administration

    Measured in \[ng/mL\]

  • Blood LD Level - Hour 7Seven hours after administration

    Measured in \[ng/mL\]

  • Blood CD Level - Hour 8Eight hours after administration

    Measured in \[ng/mL\]

  • Blood LD Level - Hour 8Eight hours after administration

    Measured in \[ng/mL\]