Ketone Ester Supplement for Brain Health
This study is looking at how a drink called Ketone Ester affects your brain. Researchers want to see if increasing ketones (a type of fuel your body makes) in your blood can change brain activity, blood flow, and how your brain uses energy. This could be important for understanding healthy brain function as we age. You would drink either the Ketone Ester or a placebo (an inactive drink) on separate visits. Scientists will measure your brain's blood flow, certain brain chemicals (glutamate and GABA), and brain activity. They are looking for changes in these areas right after you drink it. The study is for healthy adults aged 45 to 65 with a BMI between 18.5 and 30. There are 24 people planned to join this study, but its current status is unclear.
- Study design
- This is a randomized, double-blind, placebo-controlled crossover study with 24 planned participants. This means you would receive both the Ketone Ester and a placebo at different times, and neither you nor the researchers would know which you're getting at the time.
- What's involved
- You would need to come for each test session after an overnight fast and not follow a ketogenic diet during the study. You will complete two intervention periods, separated by a 3 to 7 day break.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary measurements for brain blood flow and brain chemical concentrations are taken as an acute response following a 2-day lead-in period.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Effects of Acute Ketone Supplementation on the Brain
At a glance
Conditions
Where it's being run
1 sites across 1 statesWho to contact
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What this trial measures
- Cerebral Blood FlowAcute response following 2-day lead in
To detect a clinically meaningful difference in cerebral blood flow (CBF) between ketone ester and placebo conditions in healthy adults
- Brain Glutamate ConcentrationAcute response following 2-day lead in
To detect a difference in brain glutamate concentration (mM) between ketone ester and placebo conditions in healthy adults, measured using proton magnetic resonance spectroscopy (1H-MRS).
- Brain GABA ConcentrationAcute response following 2-day lead in
To detect a difference in brain gamma-aminobutyric acid (GABA) concentration (mM) between ketone ester and placebo conditions in healthy adults, measured using proton magnetic resonance spectroscopy (1H-MRS).
- Brain Lactate ConcentrationAcute response following 2-day lead in
To detect a difference in brain lactate concentration (mM) between ketone ester and placebo conditions in healthy adults, measured using proton magnetic resonance spectroscopy (1H-MRS).
- Brain Choline ConcentrationAcute response following 2-day lead in
To detect a difference in brain choline concentration (mM) between ketone ester and placebo conditions in healthy adults, measured using proton magnetic resonance spectroscopy (1H-MRS).
- Brain N-Acetylaspartate (NAA) ConcentrationAcute response following 2-day lead in
To detect a difference in brain N-acetylaspartate (NAA) concentration (mM) between ketone ester and placebo conditions in healthy adults, measured using proton magnetic resonance spectroscopy (1H-MRS).
- Brain Glucose ConcentrationAcute response following 2-day lead in
To detect a difference in brain glucose concentration (mM) between ketone ester and placebo conditions in healthy adults, measured using proton magnetic resonance spectroscopy (1H-MRS).
- Brain Beta-Hydroxybutyrate (BHB) ConcentrationAcute response following 2-day lead in
To detect a difference in brain beta-hydroxybutyrate (BHB) concentration (mM) between ketone ester and placebo conditions in healthy adults, measured using proton magnetic resonance spectroscopy (1H-MRS).
- Functional Brain ConnectivityAcute response following 2-day lead in
Change in resting-state brain network connectivity measured using blood oxygen level-dependent functional magnetic resonance imaging (BOLD-fMRI).
- Brain Acetoacetate ConcentrationAcute response following 2-day lead in
To detect a difference in brain acetoacetate concentration (mM) between ketone ester and placebo conditions in healthy adults, measured using proton magnetic resonance spectroscopy (1H-MRS).
- Brain Glutamine ConcentrationAcute response following 2-day lead in
To detect a difference in brain glutamine concentration (mM) between ketone ester and placebo conditions in healthy adults, measured using proton magnetic resonance spectroscopy (1H-MRS).