Neural Mechanisms for Stopping Ongoing Speech Production (Study 2)
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Lingyun Zhao, PhD · PRINCIPAL_INVESTIGATOR · University of Pittsburgh
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
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What this trial measures
- Mean Change in Neural ActivityDuring inpatient hospitalization, up to 14 days after surgical electrode implantation
Neural signal recorded at each electrode (measured in voltage) is bandpass-filtered and converted to analytic amplitude using Hilbert transform, and then Z-scored relative to the entire recording block period for that electrode. A Z-score of 0 represents the mean neural activity within the recording block period, during which the task is performed. A positive Z-score indicates higher neural activity compared to the block mean. The mean change in neural activity was calculated as the difference between the average Z-score in two time windows (\~1 second after the visual cue vs. \~1 second before), averaged across trials for each electrode and then across electrodes from all participants. Positive values of the mean change in neural activity indicate that neural activity was increased after the visual cue. Since the Z-score used here is a normalized neurophysiological measure rather than a clinical scale, there are no established thresholds or definitions of better or worse outcomes.