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Peanut Butter and Prediabetes Study

This study is looking at how eating peanut butter for breakfast might affect blood sugar control, brain function, and heart disease risk in adults with prediabetes. You could be eligible if you are 40-65 years old, have a BMI between 25 and 40, and your HbA1c (a measure of average blood sugar over 2-3 months) is between 5.7-6.4%. The study will compare eating 43 grams of peanut butter daily with your usual diet. The main goal is to see if eating peanut butter changes your HbA1c after 12 weeks. The current status of this study is unclear, and it plans to enroll 56 participants.

Study design
This is a randomized, crossover study with 56 planned participants. This means you would be randomly assigned to either eat peanut butter or your usual diet first, then switch to the other condition after a break.
What's involved
You would follow either a peanut butter diet or your usual diet for 12 weeks, with a break of at least 8 weeks in between. Testing will be done at the beginning and end of each 12-week period.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured at 12 weeks, which is the duration of each study period.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07714096

Cardiometabolic & Cognitive Effects of Peanut Butter in Prediabetes

Not Yet Recruiting
NAAges 40–65InterventionalPrevention
Penn State University
~56 participants
Updated 2026-07-20 on ClinicalTrials.gov
What's tested:Peanut butterUsual diet

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in HbA1c
Measured over 12 weeks

Conditions

Prediabetes

Explore related trials

Prediabetes

Where it's being run

1 sites across 1 states
Pennsylvania1

Who to contact

Kristina Petersen, PhD
[email protected]
+1 814 865 7206
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age 40-65 years
BMI 25 to 40 kg/m2
HbA1c 5.7-6.4%
Low habitual intake of peanut butter (\<0.5 Tablespoons/day on average)
Have a smartphone device or be willing to use one provided by the study

Exclusion

Hemoglobin \<13.2 g/dL for men or \< 11.7 g/dL for women at screening
Fasting triglycerides \>350 mg/dL at screening
LDL-cholesterol ≥190 mg/dL assessed by the Martin-Hopkins equation at screening
≥10% change in body weight within the 6 months prior to enrollment
Blood pressure \>140/90 mmHg at screening
Diagnosed type 1 or type 2 diabetes
Takes any (prescription or over-the-counter) anti-hypertensive, lipid-lowering, glucose-lowering or body weight altering drugs
Intake of supplements that affect the outcomes of interest (i.e., lipids, blood pressure, glucose, body weight, and microbiome) and are unwilling to cease during the study period.
Unwilling to refrain from starting to take any supplements, vitamins, nutritional products, or health foods that are not prescribed by a doctor for the duration of the study
Self-reported history of diagnosed liver, kidney, or autoimmune disease
Self-reported history of a prior cardiovascular event (e.g., stroke, heart attack)
Self-reported history of diagnosed neurological disease (e.g. Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis)
Current pregnancy or intention of pregnancy within the next 12 months
Lactation within the prior 6 months
Peanut allergy/intolerance/sensitivity/dislike
Antibiotic use within the prior four weeks
Oral steroid use within the prior four weeks
Use of tobacco or nicotine-containing products within the past 6 months
History of cancer at any site within the past 10 years (eligible if ≥10 years without recurrence) or non-melanoma skin cancer within the past 5 years (eligible if ≥5 years without recurrence)
Participation in another clinical trial within 60 days of baseline
Currently following a restricted or weight-loss diet
Prior bariatric surgery
Intake of \>14 alcoholic drinks/week and/or not willing to avoid alcohol consumption for 48 hours prior to test visits
Does not speak and/or understand English
Unwilling to refrain from donating blood and/or plasma during the study
Weight \<110 lb
Unwilling to contact study staff before enrolling in other health-related research and avoid participating in any research that may interfere with this study
For individuals taking thyroid medication: abnormal thyroid stimulated hormone (TSH) concentration, or change in dose of thyroid medication within the last 6 months
Principal Investigator discretion related to the potential participant's ability to adhere to the study requirements, including being able to come to attend visits

What this trial measures

  • Change in HbA1c12 weeks

    HbA1c will be assessed at the beginning and end of each 12-week period and expressed as percentage. The change in HbA1c will be calculated as the post-condition value minus the pre-condition value and expressed as percentage point change.