Low Dose Radiotherapy for Osteoarthritis

This study is testing Low Dose Radiation Therapy (LDRT) for people with osteoarthritis (OA) in joints like hips, knees, hands, shoulders, ankles, or elbows. You might be able to join if you are 18 or older, have had OA for over 3 months, and your current treatments haven't worked well, or you're considering more aggressive options like joint replacement but prefer a less invasive approach. The study aims to see if LDRT can reduce pain by measuring changes in your pain levels. The current status of this study is unclear, but it plans to enroll 113 participants.

Study design
This is a single-arm study, meaning all participants receive the same intervention, and plans to enroll 113 people. It is a single institution, multi-site study.
What's involved
You will complete questionnaires (BPI-SF, PROMIS Global v1.2, UEFI, and/or LEFS) at the start, and again at 3 months and 1 year after receiving 1 or 2 courses of standard care.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 1 year after treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07715188

Low Dose Radiotherapy for Osteoarthritis

Recruiting
NAAges 18+InterventionalTreatment
Abramson Cancer Center at Penn Medicine
~113 participants
Updated 2026-07-20 on ClinicalTrials.gov
What's tested:Low Dose Radiation Therapy

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
To measure the percentage of subjects who experience a best response of 1 point or more on BPI-SF
Measured over Within 1 year
Osteoarthitis
2 sites across 1 states
Pennsylvania2

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

18 years or older
Diagnosis of OA \>3 months in hips, knees, hands, shoulders, ankles or elbows.
Refractory to standard of care therapies for OA or those who are being considered for more aggressive interventional treatment such as joint replacement, but more conservative treatment is desired.
Provision of signed and dated informed consent.

Exclusion

Unable to reasonably complete study instruments.
  • To measure the percentage of subjects who experience a best response of 1 point or more on BPI-SFWithin 1 year

    Assess the degree of patient-reported pain prior to and after use of 1-2 courses of LDRT