Understanding Vitamin E and High Blood Fat Levels

This study is looking at how high-fat meals affect vitamin E levels in your blood. Researchers want to understand if high levels of fat in the blood (hyperlipidemia) might prevent important nutrients like vitamin E from getting where they need to go in the body. You would receive three high-fat vitamin E-stripped meals as part of the study. The main goal is to measure the amount of vitamin E in your blood over 23 hours after these meals. This study is for people aged 18 to 65 who have lipid metabolism disorders (high blood fat levels), and healthy volunteers are also needed. The study is currently recruiting 48 participants.

Study design
This is an interventional study, meaning participants will receive a specific intervention (high-fat meals). It plans to enroll 48 participants.
What's involved
You will have 3 or 4 clinic visits over 3 months, with the last visit requiring a 2-night stay in the clinic. You will undergo a physical exam and blood tests, and must stop taking dietary supplements before the study.
Compensation
Not stated in the trial record.
Follow-up
Your vitamin E levels will be measured from hour 1 to hour 23 after the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07715890

Plasma Lipids-Dependent Vitamin E Metabolism During Dynamic Hyperlipidemia

Not Yet Recruiting
NAAges 18–65InterventionalBasic science
National Heart, Lung, and Blood Institute (NHLBI)
~48 participants
Updated 2026-08-03 on ClinicalTrials.gov
What's tested:High fat liquid shake

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
AUC (Area Under the Curve) of vitamin E plasma from hour 1 to hour 23 by cohort.
Measured over From hour 1 to hour 23
Lipid Metabolism Disorders
1 sites across 1 states
Maryland1
  • Robert D Shamburek, M.D. · PRINCIPAL_INVESTIGATOR · National Heart, Lung, and Blood Institute (NHLBI)

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  • AUC (Area Under the Curve) of vitamin E plasma from hour 1 to hour 23 by cohort.From hour 1 to hour 23

    Compare the effects of postprandial hypertriglyceridemia on plasma vitamin E dynamics in subjects between baseline normo- and hyperlipidemia.