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Study of BL1332 for Capsaicin-Induced Eye Pain

This study is testing BL1332 eye drops to see if they can reduce eye pain caused by capsaicin (the active ingredient in chili peppers). You might be able to join if you are a healthy adult between 18 and 65 years old and do not wear contact lenses, or are willing to stop wearing them for the study. The researchers will measure your eye pain using a numeric pain rating scale (NPRS) just 5 seconds after capsaicin is given to see if BL1332 helps. We don't have information on the current recruitment status for this study.

Study design
This is a single-center, double-masked study, meaning neither you nor the study team will know if you receive BL1332 or a placebo. It plans to enroll 28 healthy participants.
What's involved
You would receive BL1332 eye drops or placebo eye drops one time. Your eye pain would be assessed 5 seconds after a capsaicin dose.
Compensation
Not stated in the trial record.
Follow-up
Your pain will be assessed 5 seconds after a capsaicin dose. Further follow-up is not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07717918

A Study of BL1332 on Capsaicin-Induced Ocular Pain in Healthy Trial Participants

Recruiting
PHASE1Ages 18–65InterventionalTreatment
Bausch & Lomb Incorporated
~28 participants
Updated 2026-07-21 on ClinicalTrials.gov
What's tested:BL1332 eye dropsBL1332 Placebo eye drops

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Ocular pain severity assessed by numeric pain rating scale (NPRS)
Measured over Assessed 5 seconds post-capsaicin dose

Conditions

Healthy

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Healthy Volunteers

Where it's being run

1 sites across 1 states
California1

Who to contact

Celia Busby
[email protected]
9453277624
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Male or female ≥ 18 to ≤ 65 years of age.
In good health, as assessed at Screening by the Investigator from past medical history, physical examination (abbreviated), and laboratory tests.
Does not wear contact lenses, or is willing to refrain from wearing contact lenses for the duration of the study.

Exclusion

Women of childbearing potential or non-vasectomized males with partners of childbearing potential are not eligible unless they are using an effective method of contraception and agree to use an effective method of contraception until at least 30 days after study treatment.
Any medical condition (systemic or ophthalmic) that may, in the opinion of the Investigator, preclude the safe administration of IP, safe participation in this study, or confound the assessment of safety or efficacy.
Unwilling or unable to comply with the study protocol.

What this trial measures

  • Ocular pain severity assessed by numeric pain rating scale (NPRS)Assessed 5 seconds post-capsaicin dose

    NPRS scale 0 to 10, with higher score reflecting worse pain