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Furosemide Stress Test for Acute Kidney Injury in Children

This study is looking at whether a special tool added to electronic medical records can help doctors use the furosemide stress test (a test using the medicine furosemide to see how well kidneys are working) more effectively in critically ill children. These children are at high risk for severe acute kidney injury (AKI), which is when kidneys suddenly stop working well. The main goal is to see if using this tool can reduce fluid buildup and help predict which children might need dialysis (a treatment to clean the blood when kidneys fail). You might be able to join if you are in the pediatric intensive care unit (PICU) and have specific risk factors for AKI, including a high Renal Angina Index (RAI) and high urine NGAL (a biomarker). This is an observational study, meaning researchers will watch what happens in routine care rather than giving specific treatments. The study is currently unclear on its status and plans to include 120 participants.

Study design
This is an observational study that will include 120 participants. Researchers will compare outcomes in children before and after the clinical decision support tool is implemented.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants' fluid accumulation will be measured at 2 years after the intervention.

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NCT07718464

FST Analysis Supporting Timely Therapy and Risk Assessment Via Clinical Decision Support for Kids

Recruiting
Not specifiedAll AgesObservational
Children's Hospital Medical Center, Cincinnati
~120 participants
Updated 2026-07-22 on ClinicalTrials.gov
What's tested:Furosemide Stress Test Clinical Decision Support Tool

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Day 7 Fluid Accumulation
Measured over 2 years

Conditions

Acute Kidney Injury
Renal Replacement Therapy
Pediatric Intensive Care Unit

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Where it's being run

1 sites across 1 states
Ohio1

Who to contact

Natalja L Stanski, MD, MS
[email protected]
513-636-4334
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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Admitted to the pediatric intensive care unit (PICU)
Renal Angina Index (RAI) greater than or equal to 8 (RAI+)
Urine NGAL greater than or equal to 150 ng/mL (NGAL+)

Exclusion

Receipt of renal replacement therapy prior to PICU admission

What this trial measures

  • Change in Day 7 Fluid Accumulation2 years

    Median Day 7 percent fluid accumulation will be compared between eligible patients in the 2 years post-implementation and the 2 years pre-implementation. Percent fluid accumulation will be calculated as cumulative fluid balance (in liters) divided by baseline body weight (in kilograms) multiplied by 100 to obtain a percentage.