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Psilocybin for Healthy Aging and Purpose in Life

This study, called LONG-LIFE, is looking at whether psilocybin (a substance found in certain mushrooms) can affect how we age and our sense of purpose in life. Researchers will give 25mg capsules of psilocybin to older adults aged 60 to 80. They want to see if psilocybin changes biological markers (signs in your body) related to aging and improves your feeling of purpose. The study will measure these changes at 4 and 16 weeks after you start. To join, you need to be medically healthy and speak English. The study is currently unclear on its recruitment status.

Study design
This is a randomized Phase I study with up to 50 participants. You would be assigned to one of four groups, including different numbers of psilocybin doses or a wait-list group.
What's involved
You would have assessments at the beginning and then regularly over a 12-month period. This includes measuring biomarkers of aging, cognitive performance, and behavior.
Compensation
Not stated in the trial record.
Follow-up
Your progress will be followed for 12 months after the initial assessments.

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NCT07719088

Psilocybin Effects on Healthy Aging Biomarkers and Purpose in Life

Not Yet Recruiting
PHASE1Ages 60–80Interventional
Charles Raison
~50 participants
Updated 2026-07-24 on ClinicalTrials.gov
What's tested:Psilocybin (Usona Institute)

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Epigenetic/Biological Clock Profiling from Baseline to Week 4 and Week 16
Measured over Change from Baseline to Week 4 and Week 16
+1 more outcome measured

Conditions

Aging
Longevity
Biomarkers of Aging

Explore related trials

Healthy Aging

Where it's being run

1 sites across 1 states
Colorado1

Who to contact

BHIC Study Team
[email protected]
970-855-7374
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

English speaking and able to provide informed consent and complete study procedures
Medically healthy, as determined by the screening physician, with no significant medical conditions that would interfere with participation or affect the safety of the subject.

Exclusion

History or presence of any psychiatric or medical condition that, in the opinion of the investigator, could pose a safety risk, interfere with participation, or confound study results.
Abnormal ECG at screening that may increase risk during participation (e.g., prolonged QTc, arrhythmias, or other clinically significant findings as determined by the study physician).
Unwilling or unable to discontinue medications that may interfere with study participation, as determined by the investigator.

What this trial measures

  • Change in Epigenetic/Biological Clock Profiling from Baseline to Week 4 and Week 16Change from Baseline to Week 4 and Week 16

    Epigenetic/biological clock profiles; change from Baseline to Week 4 and 16

  • Change in Purpose in Life (PIL) from Baseline to Week 4 and Week 16Change from Baseline to Week 4 and Week 16

    Change from baseline in Purpose in Life score measured using the 7-item Purpose in Life Scale (PIL) from the Health and Retirement Study (score range 1-6; higher scores indicate greater purpose in life).