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Suzetrigine for Pain After Thumb Basal Joint Arthroplasty

This study is looking at how well a new, non-opioid pain medication called suzetrigine works to manage pain after thumb basal joint replacement surgery (arthroplasty). Researchers believe suzetrigine might offer good pain relief without needing opioid medications. You would receive suzetrigine and acetaminophen (Tylenol) after your surgery. The main goal is to see how much pain you have five days after surgery. This study is for people aged 40 to 80 who are having thumb basal joint replacement surgery and do not have a history of substance abuse or allergies to the study medications. The current status of this study is unclear, and it plans to enroll 100 participants.

Study design
This is an observational study, meaning researchers will observe the effects of the medication. It plans to include 100 participants.
What's involved
You would receive a loading dose of suzetrigine in the recovery room, followed by 50 mg doses every 12 hours for 5 days. You would also take acetaminophen (Tylenol) as directed.
Compensation
Not stated in the trial record.
Follow-up
Your pain will be measured for 5 days after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07723352

Journavx to Treat Pain After Thumb Basal Joint Arthroplasty

Enrolling by Invitation
Not specifiedAges 40–80Observational
Rothman Institute Orthopaedics
~100 participants
Updated 2026-07-23 on ClinicalTrials.gov
What's tested:suzetrigine 100mgAcetaminophen

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Postoperative pain
Measured over 5 days

Conditions

Thumb Basal Joint Osteoarthritis
Postoperative Pain
Joint Replacement Surgery
Joint Replacement

Explore related trials

Osteoarthrosis of the carpometacarpal joint of the thumbPost-Operative Pain

Where it's being run

1 sites across 1 states
Pennsylvania1

Study leadership

  • Camilo Restrepo, MD · STUDY_DIRECTOR · Rothman Orthopaedic Institute

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Aged 40-80 years.
Undergoing thumb basal joint arthroplasty (BJA)
Able to provide informed consent.
Willing to comply with the study procedures.

Exclusion

History of substance abuse or chronic opioid use.
Known allergies to acetaminophen, oxycodone, or suzetrigine.
Severe renal or hepatic dysfunction
Estimated glomerular filtration rate less than 15 ml/min/1.73m\^2
History of kidney transplant
Child-Pugh Class C
History of liver failure
Active hepatitis that can adversely influence hepatic function
Has had prior surgery on the study hand within the last 6 months
Is currently pregnant, planning to be pregnant, or breastfeeding
Use of strong or moderate CYP3A inhibitors or inducers, or medications known to interact with suzetrigine
Currently using a prescription pain medication other study medications

What this trial measures

  • Postoperative pain5 days

    Participants Pain will be assessed using the Numeric Rating Scale (NRS)at regular daily postoperative intervals