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Observational Study on Myelination in Older Adults with Multiple Sclerosis

This observational study is looking at how physical activity and other lifestyle factors might affect myelin, the protective coating around nerve fibers, in people aged 50 to 70 with multiple sclerosis (MS). You would not receive any new treatments. Instead, researchers will use MRI scans to measure myelin in your brain and spinal cord, and you'll wear a wrist device to track your activity. They want to see if certain lifestyle choices are linked to changes in myelin over six months. The goal is to gather initial information that could lead to future studies on preventing myelin damage and promoting repair in MS. The study plans to include 14 participants, but its current status is unclear.

Study design
This is an observational study with 14 planned participants. It is not a treatment study, but rather aims to gather information over time.
What's involved
You would have MRI scans and clinical assessments at the beginning and after 6 months. You would also wear a wrist activity monitor and complete monthly questionnaires throughout the study period.
Compensation
Not stated in the trial record.
Follow-up
Your myelin levels will be measured at the start of the study and again at 6 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07723599

Combating Age-related Failure of Myelination in Multiple Sclerosis: An Exploratory Study

Not Yet Recruiting
Not specifiedAges 50–70Observational
University of Washington
~14 participants
Updated 2026-07-23 on ClinicalTrials.gov
What's tested:Observation

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Quantitative MRI-derived myelin measure
Measured over Baseline and 6 months

Conditions

Multiple Sclerosis

Explore related trials

Multiple Sclerosis

Where it's being run

1 sites across 1 states
Washington1

Who to contact

Susan R Robles, BS
[email protected]
206-598-0501
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Diagnosis of multiple sclerosis
Independent with ambulation (able to walk 500m without aid)
Disease duration \>10 years
Age 50 to 70 years (inclusive)
Be able to read, speak, and understand English

Exclusion

Diagnosis of other neurologic disease that would interfere with interpretation such as stroke, myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), neuromyelitis optica (NMO), and sarcoidosis.
Inability to complete study procedures (including obtaining MRI at BMIC and using Fitbit connected to smartphone)
Currently participating in another clinical trial on remyelination
Pregnancy. (Pregnancy status will be asked at screening and before each MRI. Pregnancy testing will not be offered as part of this study.)

What this trial measures

  • Quantitative MRI-derived myelin measureBaseline and 6 months

    Change in MRI-derived measures of myelin content within the central nervous system. Specifically, the investigators will use macromolecular proton fraction (MPF), a quantitative MRI parameter which describes the magnetization transfer effect and defined as the relative amount of protons bound to biological macromolecules with restricted molecular motion.