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Study of Lidocaine with Epinephrine for Dermatological Procedures

This study is looking at how long the numbing effect of lidocaine HCl/Epinephrine lasts when injected into different layers of the skin on your forearm. Researchers want to see if injecting this common local anesthetic (numbing medicine) just under the skin (subcutaneous) versus into the skin itself (intradermal) changes how long you stay numb. You might be able to join if you are 18 or older, have normal skin sensation on your nose and forearms, and can give your consent. The study will measure how long the numbing lasts and how quickly it starts. The current recruitment status is unclear, but the study plans to enroll 50 participants.

Study design
This is an interventional study comparing two ways of injecting lidocaine HCl/Epinephrine in the same participant. It plans to enroll 50 participants.
What's involved
You will receive injections of lidocaine HCl/Epinephrine into your forearm. Researchers will then test your skin sensation to measure how long the numbing lasts, up to 6 hours, and how quickly it starts, up to 10 minutes.
Compensation
Not stated in the trial record.
Follow-up
Your sensation will be monitored from the time of injection until the return of sharp sensation, up to 6 hours.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07724418

Split Face Study of the Duration of Local Anesthetics - Fifth Arm

Not Yet Recruiting
PHASE4Ages 18+InterventionalTreatment
Weill Medical College of Cornell University
~50 participants
Updated 2026-07-24 on ClinicalTrials.gov
What's tested:Lidocaine HCl/Epinephrine

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Duration of anesthesia
Measured over From injection until return of sharp sensation, up to 6 hours
+1 more outcome measured

Conditions

This Study Will Focus on In-office Dermatological Procedures

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Where it's being run

1 sites across 1 states
New York1

Study leadership

  • Kira Minkis, MD, PhD · PRINCIPAL_INVESTIGATOR · Weill Medical College of Cornell University

Who to contact

Kira Minkis, MD, PhD
[email protected]
6469627948
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Male or female ≥ 18 years of age
Normal skin sensation at both nasal ala and volar forearms assessed by pinprick
Ability to provide informed consent

Exclusion

Previous adverse reaction to local anesthetic or any components of the local anesthetics being evaluated
Pregnant or breastfeeding volunteers (assessed by self-report)
Patients taking monoamineoxidase inhibitors (MAOI) or antidepressants of the triptyline or imipramine types

What this trial measures

  • Duration of anesthesiaFrom injection until return of sharp sensation, up to 6 hours

    Time (in minutes) from onset of anesthesia (loss of sharp sensation at the injection site) to return of sharp sensation.

  • Onset of anesthesiaImmediately following injection until loss of sharp sensation, up to 10 minutes

    Duration (in minutes) between anesthetic administration to loss of sensation to sharpness at injection site.