VNS Algorithm for Advanced Dosing in Epilepsy

This study is looking at adults with epilepsy who are candidates for a Vagus Nerve Stimulator (VNS) implant. The VNS is a device that helps control seizures. The study compares two ways of programming the VNS device: "Standard VNS programming" (the usual way) and "Rapid Titration VNS programming" (a modified, faster approach). The main goal is to see if the Rapid Titration VNS programming can reduce seizures more quickly than the standard method. You could join if you are between 18 and 75 years old and are planning to get a VNS implant for epilepsy. The study plans to enroll 80 people.

Study design
This study will compare two different VNS programming methods in 80 participants. It is an interventional study, meaning participants will receive one of the two programming methods.
What's involved
You would attend up to 3 study visits every 3 months for 2 years. You would also answer questionnaires about your quality of life and thinking, and keep a diary of your seizure activity.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for seizure activity from enrollment until the end of participation at 2 years.

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NCT07725601

VNS Algorithm for Advanced Dosing

Recruiting
NAAges 18–75InterventionalTreatment
Fernando Vale
~80 participants
Updated 2026-07-24 on ClinicalTrials.gov
What's tested:Rapid Titration VNS programmingStandard VNS programming

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Seizure Diary
Measured over From enrollment to end of participation at 2 years
Epilepsies
1 sites across 1 states
Georgia1

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Eligibility criteria

Inclusion

Subjects who are clinically determined to be candidates for VNS implantation for seizure control
Subject/legally authorized representative able to provide informed consent.

Exclusion

Subjects with VNS system treating pathologies other than drug refractory epilepsy or medical co-morbidities that prevent any surgical intervention
  • Seizure DiaryFrom enrollment to end of participation at 2 years

    A seizure diary is a personalized log used to record seizure activity, medication adherence, and potential triggers