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Tissue Preservation in Immediate Dental Implants

This study is looking at a new type of dental implant part called an anatomical prefabricated healing abutment (AHA). It's designed to help keep the gum tissue around your implant healthy and looking natural after a tooth is removed and an implant is placed right away. Researchers want to see if the AHA works better than a standard healing abutment, which has a more basic shape. They will measure changes in your gum tissue over 12 months. You might be able to join if you are between 20 and 75 years old, need a back tooth replaced with an immediate implant, and are generally healthy. The current status of this study is unclear.

Study design
This is an interventional study with a planned enrollment of 30 participants. It is a randomized controlled trial, meaning participants will be randomly assigned to receive either the anatomical prefabricated healing abutment or a standard healing abutment.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 12 months after treatment to measure changes in their gum tissue.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07727980

Tissue Preservation in Immediate 1C Implants Using an Anatomical Prefabricated Healing Abutment

Not Yet Recruiting
NAAges 20–75InterventionalTreatment
University of Illinois at Chicago
~30 participants
Updated 2026-07-27 on ClinicalTrials.gov
What's tested:scannable anatomical healing abutmentStandard Healing Abutment for Dental Implants

At a glance

Recruiting sites
0 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Three-dimensional (3D) peri-implant soft tissue volumetric changes within the region of interest (ROI)
Measured over From enrollment to the end of treatment at 12 months follow-up

Conditions

Tooth Loss
Dental Implant
Clinical Trials
Randomized Controlled Trial
Immediate Dental Implant Placement
Molar Extraction Socket
Maxilla
MANDIBLE

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Tooth Loss

Where it's being run

2 sites across 2 states
Illinois1
Indiana1

Study leadership

  • Luis Mezzomo, PhD · PRINCIPAL_INVESTIGATOR · University of Illinois at Chicago
  • Waldemar Polido, PhD · PRINCIPAL_INVESTIGATOR · Indiana University

Who to contact

Luis Mezzomo, PhD
[email protected]
312-996-3535
Email the study team

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Eligibility criteria

Inclusion

Willing to sign an IRB-approved informed consent and HIPAA authorization form prior to participation.
Between the ages of 20 and 75 years old.
ASA Classification I and II.
Hopeless maxillary or mandibular posterior teeth, eligible for immediate implantation, and with intact/successfully restored adjacent teeth.
Willing to perform tasks associated with the study and to attend all study visits.
Sites with an intact or minimally damaged facial bone plate measuring greater than 1 mm in thickness;
Sites with at least 5 mm of healthy bone between the socket apex and the relevant anatomical structure (e.g., the maxillary sinus floor in the maxilla or the inferior alveolar nerve, submandibular/sublingual fossa, mental foramen, or anterior loop of the inferior alveolar nerve in the mandible);
In multirooted molar sockets, the presence of a short root trunk and an interradicular septum with a minimum height of 5 mm and a thickness of 3 mm.

Exclusion

HbA1c \>6.5%) as per a chairside test (Siemens Bayer DCA 2000+);
smoker (any status);
immunodeficiency;
history of head and neck radiotherapy;
intake of bone anti-resorptive drugs;
cysts or tumors in the area;
self-reported pregnancy;
poor oral hygiene;
active periodontal disease;
acute endodontic infection and pus discharge on the site itself and adjacent areas;
lack of mutually protected occlusion;
insufficient inter-occlusal clearance (\<15 mm);
sites with an existing midfacial mucogingival recession/deficiency (scar tissue);
sites with a high-scalloped, thin biotype.

What this trial measures

  • Three-dimensional (3D) peri-implant soft tissue volumetric changes within the region of interest (ROI)From enrollment to the end of treatment at 12 months follow-up

    To assess soft tissue three-dimensional (3D) volumetric changes by calculating the percentage variation in cubic millimeters (% mm³) within defined regions of interest (ROI), using superimposed consecutive digital surface models (intraoral scans) obtained at pre-extraction (T1), impression (T3), baseline/prosthesis delivery (T4), 6 months (T5), and 12 months (T6), at the Geomagic® metrology software. This endpoint will assess the ability of the scannable anatomical healing abutment to preserve peri-implant soft tissue contours following immediate implant placement. Longitudinal changes will be analyzed using mixed-effects models to evaluate the interaction between treatment group and time.