Study of Topical-Lingual Semaglutide for Obesity

This study is looking at a new way to deliver semaglutide, a medicine often used for weight management. We are testing a liquid form of semaglutide that you would apply to your tongue, comparing it to the standard Wegovy® (semaglutide) Tablet and a placebo (an inactive substance). The main goal is to see how much body weight changes over 24 weeks. You might be able to join if you are an adult between 18 and 65 years old with a Body Mass Index (BMI) between 30 and 45. You cannot join if you have Type 2 Diabetes Mellitus, Multiple Endocrine Neoplasia Type 2, or Medullary thyroid cancer. This study is currently recruiting 40 participants.

Study design
This is an interventional study comparing three different treatments: semaglutide liquid emulsion, Wegovy® tablets, and a placebo liquid emulsion. It plans to enroll 40 adult participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome of body weight change is measured at 24 weeks.

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NCT07728383

A Proof-of-Concept Study to Evaluate Topical-Lingual Semaglutide in Adults With Obesity

Recruiting
PHASE4Ages 18–65InterventionalTreatment
Gila Therapeutics, Inc.
~40 participants
Updated 2026-07-27 on ClinicalTrials.gov
What's tested:Semaglutide 6 mg liquid emulsion formulationWegovy® (semaglutide) TabletPlacebo liquid emulsion formulation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percent body weight change from baseline
Measured over 24 weeks
Obesity & Overweight
1 sites across 1 states
Minnesota1
  • Thomas Vasicek, Ph.D. · STUDY_CHAIR · Gila Therapeutics, Inc.

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Body Mass Index 30 to 45

Exclusion

Type 2 Diabetes Mellitus
Multiple Endocrine Neoplasia Type 2
Medullary thyroid cancer
  • Percent body weight change from baseline24 weeks

    Percentage change in body weight at 24 weeks from baseline by calibrated scale.