A Study of an Updated COVID-19 Vaccine in Healthy Adults

This study is looking at the safety and effects of an updated COVID-19 vaccine called BNT162b2 in healthy adults aged 18 to 64. You might be able to join if you are medically stable, haven't had COVID-19 recently, and haven't received another vaccine recently. Participants will receive one injection of either the BNT162b2 vaccine or a Tdap vaccine (for tetanus, diphtheria, and whooping cough). Neither you nor the study team will know which vaccine you receive. Researchers will check for any reactions or side effects to understand how safe the vaccines are. The study aims to enroll 200 people, but its current recruitment status is unclear.

Study design
This is an interventional study where participants will randomly receive one of two vaccines. The study plans to enroll 200 participants.
What's involved
Participants will receive a single injection on Day 1. Researchers will monitor for local reactions and systemic events for 7 days, and for adverse events for 1 month.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for serious adverse events for up to 12 months after vaccination.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07730450

A Study to Learn About a COVID-19 Vaccine in Healthy Adults 18 Through 64 Years of Age

Not Yet Recruiting
PHASE4Ages 18–64InterventionalPrevention
BioNTech SE
~200 participants
Updated 2026-07-28 on ClinicalTrials.gov
What's tested:BNT162b2 VaccineTdap Vaccine

At a glance

Recruiting sites
0 of 4 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percentage of participants reporting local reactions or systemic events
Measured over From Day 1 up to 7 days after Vaccination
+3 more outcomes measured
COVID-19 Vaccines
4 sites across 4 states
California1
Florida1
Hawaii1
Utah1
  • Pfizer CT.gov Call Center · STUDY_DIRECTOR · Pfizer

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Do you actually qualify for this trial?

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Eligibility criteria

Exclusion

Participants who tested positive for COVID-19 within 6 months (180 days) prior to Visit 1
Participants who have recently received a vaccine, or plan to receive a nonstudy COVID-19 or comparator vaccine during participation.
  • Percentage of participants reporting local reactions or systemic eventsFrom Day 1 up to 7 days after Vaccination
  • Percentage of participants reporting adverse eventsFrom Day 1 through 1 month after vaccination
  • Percentage of participants reporting serious adverse eventsFrom Day 1 through 12 months after vaccination
  • Spike protein levelsUp to 12 months after vaccination