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SC2i Tissue and Data Repository for Critical Illness

This study is collecting samples like blood, urine, and wound tissue from people who are seriously injured or ill, as well as from healthy volunteers. The goal is to create a collection of these samples to help doctors develop better tests and tools for treating critically ill military personnel and civilians. This study is observational, meaning researchers are collecting information without giving any specific treatments. Success for this study means building a valuable collection of samples that can be used for future research. The current recruitment status is unclear.

Study design
This is an observational study planning to enroll 5000 participants. It involves collecting samples from people with critical illness and healthy volunteers.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Samples will be stored indefinitely in the repository.

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NCT02182180

SC2i Tissue and Data Repository Protocol

Recruiting
Not specifiedAges 18+Observational
Henry M. Jackson Foundation for the Advancement of Military Medicine
~5,000 participants
Updated 2025-09-04 on ClinicalTrials.gov

At a glance

Recruiting sites
4 of 4 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Collecting, processing and archiving human tissue
Measured over Samples will be stored indefinitely in repository

Conditions

Critical Illness

Explore related trials

Critical Illness

Where it's being run

4 sites across 3 states
Georgia2
Maryland1
North Carolina1

Study leadership

  • CAPT Eric Elster, MD, US Navy · STUDY_DIRECTOR · Uniformed Services University of the Health Sciences
  • Allan M. Kirk, MD, PhD · PRINCIPAL_INVESTIGATOR · Duke University
  • Timothy G Buchman, Ph.D, MD · PRINCIPAL_INVESTIGATOR · Emory University
  • Christopher J. Dente, MD · PRINCIPAL_INVESTIGATOR · Grady Hospital
  • Benjamin K Potter, MD, FACS · PRINCIPAL_INVESTIGATOR · Uniformed Services University - Walter Reed Surgery

Who to contact

Christopher J. Dente, MD
[email protected]
404-251-8915
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Eligibility criteria

Inclusion

Patients with injury or illness requiring surgical care or treatment in a critical care or emergency setting who are being cared for at SC2I sites (Grady Memorial Hospital, Emory Univeristy Hospital, and Duke University Health Systems)
Healthy volunteer control subjects to include individuals without any known injury or end-stage organ disease and patients who have recovered from prior injury.
Ability to understand the purposes and risks of the study and willingly give written informed consent, or in the case of incapacitated patients, a willing surrogate able to give written informed consent.

Exclusion

Any condition that, in the opinion of the attending physician, would place the patient or volunteer subject at undue risk by participating. Specific conditions include but are not limited to anemia prohibitive of phlebotomy, coagulopathy, or technical considerations that would prevent acquisition of sufficient tissue or fluid for clinical use. Acquisition of samples from patients requiring active transfusion or with transfusion-associated coagulopathy will be considered as appropriate study candidates at the discretion of the attending physician.

What this trial measures

  • Collecting, processing and archiving human tissueSamples will be stored indefinitely in repository

    Samples of blood, urine, cerebrospinal fluid, wound tissue and/or wound fluids, and other body fluids and tissues from people who have been seriously injured or ill will be collected. The samples will be used to develop and assess tests and/or tools that doctors can use to decide the best treatment plan for seriously injured or ill military personnel and for civilians. Additional research on the samples will be under separate protocols. This is a collection protocol.