Establishing Normative Data for Pupillometer Assessments in Neuro-Intensive Care

This study aims to collect a large amount of data on how pupils react in patients who are critically ill. Researchers are looking to understand what normal pupillometer readings (measurements of your pupil's size and how it reacts to light) look like in the intensive care unit (ICU). This information will help fill a gap in our knowledge about these readings. You may be able to join if you are admitted to one of the participating hospitals and your doctor has ordered regular pupillary assessments using a pupillometer. The main goal is to establish normal values for pupillometer data, including pupil size, reactivity, and a neurological pupil index (NPi). This study is currently unclear on its recruitment status and plans to enroll 1000 participants.

Study design
This is an observational study that plans to enroll 1000 participants. It is not testing a specific intervention or drug.
What's involved
Data will be collected on patients who are already having regular pupillary assessments as part of their care in the ICU.
Compensation
Not stated in the trial record.
Follow-up
Pupillary variance will be measured daily at 9:00 am during ICU admission.

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NCT02804438

Establishing Normative Data for Pupillometer Assessments in Neuro-Intensive Care

Recruiting
Not specifiedAll AgesObservational
University of Texas Southwestern Medical Center
~1,000 participants
Updated 2025-10-22 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Oculomotor evaluation of pupillary variance during ICU admission
Measured over Daily at 9:00am
Critical Illness
Neuropathy
1 sites across 1 states
Texas1

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Eligibility criteria

Inclusion

Data will be collected on patients admitted to enrolling hospitals who have been assigned, by the attending physician, to have regular pupillary assessments, and in whom staff nurses are performing pupillary assessments with the pupillometer.

Exclusion

Out-patients
Patients that do not have orders for regular pupillary assessments
  • Oculomotor evaluation of pupillary variance during ICU admissionDaily at 9:00am

    Pupil size and reactivity per neurological pupil index