Retinal Imaging in Neurodegenerative Disease
This observational study is looking at how non-invasive eye scans, called Optical Coherence Tomography (OCT), OCT Angiography (OCTA), and ultra-widefield (UWF) fundus photography, can help us understand conditions like Alzheimer's Disease, Parkinson's Disease, and Multiple Sclerosis. These scans look at the tiny blood vessels and structures in the back of your eye (retina and choroid). Researchers believe changes in your eyes might show what's happening in your brain. They will measure changes in specific layers of your retina (GCIPL, RNFL, and CST) over one year. You can join if you are an adult with or without a neurodegenerative disease, as long as you can cooperate with the eye tests. The study aims to see if these eye scans can be a useful tool for early detection of these diseases.
- Study design
- This is an observational study with a planned enrollment of 2000 participants. It is not specified if it is randomized or blinded.
- What's involved
- You would undergo non-invasive OCT, OCTA, and UWF fundus photography of your retina at the start of the study and again after one year.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for one year, with measurements taken at baseline and at the one-year mark.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Retinal Imaging in Neurodegenerative Disease
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Sharon Fekrat, MD FACS FASRS · PRINCIPAL_INVESTIGATOR · Duke University
- Dilraj Grewal, MD · PRINCIPAL_INVESTIGATOR · Duke University
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Change in ganglion cell-inner plexiform layer (GCIPL) thicknessBaseline, 1 year
Ganglion cell inner plexiform layer thickness as measured on optical coherence tomography scan of macula
- Change in retinal nerve fiber layer (RNFL) thicknessBaseline, 1 year
Retinal nerve fiber layer thickness as measured on optical coherence tomography scan of macula
- Change in central subfield thickness (CST)Baseline, 1 year
Central subfield thickness as measured on optical coherence tomography scan of macula
- Change in choroidal vascularity index (CVI)Baseline, 1 year
Choroidal vascularity index as measured using the COIN software in 1500 um area centered on the fovea
- Change in foveal avascular zone (FAZ) areaBaseline, 1 year
Foveal avascular zone area as measured in the superficial capillary plexus on 3mm optical coherence tomography angiography scan of the macula
- Change in average perfusion density (PD)Baseline, 1 year
Average perfusion density as measured in the ETDRS 3mm and 6mm circle and rings on optical coherence tomography angiography scan of the macula
- Change in average vessel density (VD)Baseline, 1 year
Average vessel density as measured in the ETDRS 3mm and 6mm circle and rings on optical coherence tomography angiography scan of the macula
- Change in average capillary perfusion density (CPD)Baseline, 1 year
Capillary perfusion density as measured on peripapillary 4.5mm optical coherence tomography angiography scan
- Change in average capillary flux index (CFI)Baseline, 1 year
Capillary flux index as measured on peripapillary 4.5mm optical coherence tomography angiography scan