Brain Connectivity in Depression Study
This study is looking at how brain connections relate to depression and how people respond to treatments like repetitive Transcranial Magnetic Stimulation (rTMS) and intermittent theta burst stimulation (iTBS). Researchers want to understand if brain activity patterns can predict how well these treatments will work for you. You can join if you are 18 or older and have received or will receive daily TMS treatment for depression that hasn't responded to other medications. The study involves MRI scans and behavioral tests. The main goal is to see if brain connectivity can predict how well rTMS and iTBS work one year after treatment. The study aims to enroll 260 participants, but its current status is unclear.
- Study design
- This is an interventional study planning to enroll 260 participants. It is not specified if it is randomized or blinded.
- What's involved
- You would undergo an hour-long MRI scan, complete a series of cognitive tasks, and may have up to three 20-minute neuronavigation sessions.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your clinical response to treatment will be measured one year after the study completion.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Brain Connectivity in Depression
At a glance
Conditions
NCT03276793
Where you'd take part
This study runs at 4 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Brigham and Women's Hospital
Boston, Massachusettsstudy coordinator listed
Recruiting
Massachusetts General Hospital
Boston, Massachusettsstudy coordinator listed
Recruiting
Beth Israel Deaconess Medical Center
Boston, Massachusettsno site contact published
Completed
Butler Hospital
Providence, Rhode Islandno site contact published
Active, not recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Prediction of repetitive Transcranial Magnetic Stimulation (rTMS) clinical response1 year after study completion
Connectivity between each patient's stimulation site and the subgenual cingulate will be used to predict clinical response to rTMS in the first group (data collected starting in 2017).
- Prediction of intermittent theta burst stimulation (iTBS) clinical response1 year after study completion
Normative connectivity of each patient's stimulation site to a previously-published "depression network" (Siddiqi et al., Nat Hum Behav 2021) will be used to predict clinical response to iTBS in the second group added in September 2022.