This study aims to understand if there is more brain inflammation in people with neuropsychiatric syndromes like mood disorders, chronic pain, or dementia. Researchers will use a special imaging technique called PET (Positron Emission Tomography) with a tracer called [11C]PBR-28 or [11C]ER176. These tracers help detect inflammation in the brain. The study will also look at whether the amount of inflammation is related to the severity of symptoms. You might also undergo an "affective challenge," which involves inducing certain moods or pain. The main goal is to measure the level of a protein called TSPO, which indicates brain inflammation, using these PET scans. This study is recruiting up to 200 participants, including healthy individuals and those with neuropsychiatric syndromes, aged 18 to 80.

Study design

This is an interventional study, meaning participants will receive a specific intervention. It plans to enroll 200 participants.

What's involved

You would receive an injection of [11C]PBR-28 or [11C]ER176 during a PET scan, which occurs between 1:30 PM and 3 PM. You would also undergo an affective challenge. You must be able to sit still for long periods.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoint is measured during the PET scan at study baseline, within a few days of enrollment. No further follow-up is specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.