Bright Light Exposure for Cardiac Surgery Patients

This study is looking at whether exposure to bright light before and after heart surgery can help patients. Researchers are testing two types of light: "Day Light" (bright light) and "Placebo light" (dim light). You would be exposed to one of these lights for up to 10 days before surgery, and if you are in the ICU, for up to 10 days after surgery. The main goal is to see how these lights affect levels of a protein called Per2 in your body. They also want to see if bright light can lead to lower levels of Troponin I (a marker of heart damage) after surgery. This study is for people aged 18 to 90 who are having their first open-heart surgery and are in a normal heart rhythm. The study is currently unclear on its recruitment status and plans to enroll 70 participants.

Study design
This interventional study plans to enroll 70 participants. It compares bright light exposure to placebo light exposure both before and after cardiac surgery.
What's involved
You would use a light box for 30 minutes each morning for 7 days before surgery. Blood and buccal swab samples would be collected before and after this light therapy, and a small piece of heart tissue would be taken during surgery. Another blood sample would be taken 72 hours after surgery.
Compensation
Not stated in the trial record.
Follow-up
Blood samples will be collected 72 hours after surgery to measure Troponin I levels.

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NCT03822949

Bright Light Exposure in Surgical Patients

Recruiting
NAAges 18–90InterventionalPrevention
University of Colorado, Denver
~70 participants
Updated 2025-05-14 on ClinicalTrials.gov
What's tested:Day LightPlacebo lightICU Intense LightICU Placebo light

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change of Period 2 (Per2) protein levels
Measured over 1-10 days
Myocardial Ischemia
Critical Illness
Endothelial Dysfunction
1 sites across 1 states
Colorado1
  • Tobias Eckle, MD, PhD · PRINCIPAL_INVESTIGATOR · UC Denver

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Eligibility criteria

Inclusion

Patients undergoing primary sternotomy cardiac surgery
Subjects in the range of 18 - 90 years old .
Patient need to be in sinus rhythm at the time of surgery.

Exclusion

patients \<18 or \>90 years old
participation in other clinical trials within the previous 30 days
pregnancy
neurological conditions that could impair weaning from ventilator support
significant CNS disorders or comorbid irreversible conditions with a six-month mortality rate more than 50 percent
prisoners, or subjects with altered capabilities to make decision will be enrolled
medical history of type 2 diabetes
patients with atrial fibrillation or use of class III anti-arhythmic drug
patients with a left ventricle ejection fraction \< 40%
patient in emergency condition
  • Change of Period 2 (Per2) protein levels1-10 days

    Measure of Per2 protein levels related to daylight exposure vs. room light exposure.