This observational study is looking at how changes in the GBA gene are linked to Parkinson's disease. Researchers will use special brain scans called PET scans to look at dopamine, acetylcholine (a brain chemical), and tau protein (a protein that can build up in the brain) in people with and without Parkinson's disease who have a GBA gene mutation. They will also analyze typing patterns using a computer or touch-screen device. The goal is to understand the molecular and clinical reasons behind the connection between GBA mutations and Parkinson's disease. You may be able to join if you are 18-80 years old and have a specific GBA gene mutation. The study is currently unclear on its recruitment status.

Study design

This is an observational study planning to enroll 25 participants. It will include 10 people with Parkinson's disease and a GBA mutation, and 15 people with a GBA mutation but no Parkinson's symptoms.

What's involved

Participants will have a clinical evaluation, a typing session, a brain MRI, and three PET scans.

Compensation

Not stated in the trial record.

Follow-up

Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.