This study is looking at whether a combination of two existing medications, buspirone and melatonin, can help people who experience depression after a traumatic brain injury (TBI). Previous research suggests this combination might improve depressive symptoms in people with general depression, and also help with thinking difficulties. This study will give participants either 15mg of buspirone once daily and 3mg of melatonin once nightly. Researchers will measure changes in depression symptoms after 6 weeks to see if the treatment is effective. You may be able to join if you are between 18 and 64 years old and had a mild or moderate TBI at least three months ago. The study plans to enroll 10 participants, but its current status is unclear.

Study design

This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 10 participants.

What's involved

Not specified in the trial record.

Compensation

Not stated in the trial record.

Follow-up

Depression symptoms will be measured at 6 weeks after starting treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.