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PICU Up! Early Mobility for Critically Ill Children

This study is testing an intervention called "PICU Up!" to see if it can help critically ill children in the intensive care unit (PICU). "PICU Up!" is a program that helps determine the right activity level for each child every day, with a plan tailored to their individual needs. The study aims to see if this program can reduce how long children need to be on a breathing machine (mechanical ventilation). You might be able to join if your child is under 18, has been on a breathing machine for at least 48 hours, and does not have certain conditions like an open chest or being on ECMO (a type of life support). The study plans to include 1440 children, but its current status is unclear.

Study design
This is an interventional study, meaning participants will receive a specific intervention. It plans to enroll 1440 children.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, duration of mechanical ventilation, is measured through Day 21.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04989790

Clinical Effectiveness of the "PICU Up!" Multifaceted Early Mobility Intervention for Critically Ill Children

Recruiting
NAUp to 18InterventionalHealth services
Johns Hopkins University
~1,440 participants
Updated 2026-08-24 on ClinicalTrials.gov
What's tested:PICU Up!

At a glance

Recruiting sites
10 of 11 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Duration of Mechanical Ventilation
Measured over Through Day 21

Conditions

Child
Intensive Care Unit Acquired Weakness
Critical Illness
Hospital Acquired Pressure Ulcer

Explore related trials

Critical IllnessHospital Acquired Pressure UlcerIntensive Care Unit Acquired WeaknessPost-Intensive Care Syndrome

Where it's being run

11 sites across 11 states
California1
Florida1
Kentucky1
Maryland1
Minnesota1
New Hampshire1
North Carolina1
Pennsylvania1

Study leadership

  • Sapna Kudchadkar, MD, PhD · PRINCIPAL_INVESTIGATOR · Johns Hopkins University

Who to contact

Sapna R Kudchadkar, MD, PhD
[email protected]
410-955-6412
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Invasive mechanical ventilation via oral or nasal endotracheal tube ≥ 48 hours at 7 a.m. on PICU Day 3

Exclusion

Active or anticipated withdrawal of life support within 48 hours
Open chest or open abdomen
Current use of Extracorporeal Membrane Oxygenation (ECMO)

What this trial measures

  • Duration of Mechanical VentilationThrough Day 21

    In computing duration of mechanical ventilation, the investigators will consider Time 0 as the time of endotracheal intubation or PICU admission for patients intubated at an outside hospital, and continuing until the first time the endotracheal tube was continuously absent for at least 24 hours. Patients will be assigned 21 days for ventilation duration if they remain intubated and mechanically ventilated, are transferred to another facility while ventilated or die prior to day 21 without ever remaining off mechanical ventilation ventilation (via endotracheal tube) for more than 24 continuous hours. If a patient is transitioned to mechanical ventilation via a new tracheostomy those days will be counted as mechanical ventilation days.