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NCT05152992

Spatiotemporal Dynamics of the Human Emotion Network

Enrolling by Invitation
NAAges 18–80InterventionalBasic science
University of California, San Francisco
~100 participants
Updated 2026-06-23 on ClinicalTrials.gov
What's tested:Viewing visual stimuli and electrical stimulation of the brain

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Mean Change from Baseline in Heart Rate
Measured over During inpatient hospitalization, approximately 4-14 days
+4 more outcomes measured

Conditions

Epilepsy
Depression
Anxiety
Emotions

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AnxietyDepressionSeizure Disorder

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Edward F Chang, MD · PRINCIPAL_INVESTIGATOR · University of California, San Francisco
  • Virginia Sturm, PhD · PRINCIPAL_INVESTIGATOR · University of California, San Francisco

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

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Eligibility criteria

Inclusion

Participants with epilepsy at UCSF undergoing surgical electrode implantation for seizure localization and
Participants with electrodes implanted in at least two regions of interest who are willing and able to cooperate with study tasks.

Exclusion

Participants who lack capacity or decline to provide informed consent,
Participants who have significant cerebral lesions or
Participants with cognitive deficits that preclude reliable completion of study tasks.

What this trial measures

  • Mean Change from Baseline in Heart RateDuring inpatient hospitalization, approximately 4-14 days

    The mean change from baseline in heart rate is calculated as the average change in heart rate across trials of each emotion video type and stimulated network hub (units: beats/minute). The change from baseline in heart rate on each trial is calculated as: change = (mean heart rate during a trial) - (mean heart rate prior to the trial). Note: this is one of three components of the autonomic nervous system activity outcome measure.

  • Mean Change from Baseline in Respiratory RateDuring inpatient hospitalization, approximately 4-14 days

    The mean change from baseline in respiratory rate is calculated as the average change in respiratory rate across trials of each emotion video type and stimulated network hub (units: breaths/minute). The change from baseline in respiratory rate on each trial is calculated as: change = (mean respiratory rate during a trial) - (mean respiratory rate prior to the trial). Note: this is one of three components of the autonomic nervous system activity outcome measure.

  • Mean change from Baseline in Electrodermal ActivityDuring inpatient hospitalization, approximately 4-14 days

    The mean change from baseline in Electrodermal Activity (EDA) is calculated as the average change in EDA across trials of each emotion video type and stimulated network hub (units: microsiemens).The change from baseline in electrodermal activity on each trial is calculated as: change = (mean electrodermal activity during a trial) - (mean electrodermal activity prior to the trial). Note: this is one of three components of the autonomic nervous system activity outcome measure.

  • Mean Facial Expression ActivityDuring inpatient hospitalization, approximately 4-14 days

    Mean facial expression activity (units: activation intensity) is quantified for each video emotion type and stimulated network hub. This is measured using the validated Emotional Facial Action Coding System (FACS) to provide a continuous rating of activity in 28 facial muscles using an intensity scale from 1 (trace) to 5 (maximum). The activity scores of all muscles and across the duration of a trial will be summed to quantify the total facial expression activity of that trial. Trials will be averaged for each video emotion type and stimulated network hub to obtain mean facial expression activity.

  • Mean Change from Baseline in Neural Activity within the Emotion NetworkDuring inpatient hospitalization, approximately 4-14 days

    The mean change from baseline in neural activity is calculated as the average change in neural activity across trials of each emotion video type and stimulated network hub (units: z-scored neural activity relative to the pretrial baseline). The change from baseline in neural activity on each trial is calculated as: change = (z-scored mean neural activity across the network during a trial) - (z-scored mean neural activity across the network prior to the trial).