WellPATH-PREVENT: A Mobile Intervention for Suicidal Ideation or Attempt

This study is testing a new mobile app called WellPATH-PREVENT for middle-aged and older adults (ages 50-90) who have recently been hospitalized for suicidal thoughts or a suicide attempt. The goal is to see if using the WellPATH-PREVENT app, which includes training and coaching, can help improve how you manage your emotions (called cognitive reappraisal) and reduce the risk of suicide. The study will enroll 115 participants. We are looking to see if WellPATH-PREVENT can help people feel better and reduce their risk of suicide after leaving the hospital. The study status is currently unclear.

Study design
This study is interventional and will involve about 115 participants. It has two phases: an initial 'proof-of-concept' phase and a second phase where participants will be randomly assigned to either an optimized WellPATH-PREVENT or a control group.
What's involved
You would use the WellPATH tablet app, attend training meetings during hospitalization, and have virtual coaching meetings after discharge for 6 or 12 weeks. You would also have assessments at study entry, discharge, and at various points up to 24 weeks, including an EEG (a test that measures brain activity).
Compensation
Not stated in the trial record.
Follow-up
Participants in the R61 phase will be followed for 12 weeks, and participants in the R33 phase will be followed for 24 weeks after study entry.

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NCT05183230

WellPATH-PREVENT: A Mobile Intervention for Middle-Aged and Older Adults Hospitalized for Suicidal Ideation or Attempt

Recruiting
NAAges 50–90InterventionalPrevention
Weill Medical College of Cornell University
~115 participants
Updated 2025-10-29 on ClinicalTrials.gov
What's tested:WellPATH-PREVENTOptimized WellPATH-PREVENT

At a glance

Recruiting sites
1 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Event Related Potential - Late Positive Potential (ERP/LPP) - R61
Measured over Study Entry, Week 6, Week 12
+9 more outcomes measured
Suicide, Attempted
Suicidal Ideation
Depression

NCT05183230

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • New York Presbyterian Hospital/Weill Cornell Medicine

    New York, New Yorkstudy coordinator listed

    Not yet recruiting

  • Weill Cornell Institute of Geriatric Psychiatry, Weill Cornell Medicine

    White Plains, New Yorkstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Dimitris Kiosses, PhD · PRINCIPAL_INVESTIGATOR · Weill Medical College of Cornell University

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Eligibility criteria

Inclusion

50-90 years old
Diagnosis (based on a modified SCID-5 Clinical Trials Version to assess DSM-5 diagnoses): Any DSM-5 except: current diagnosis of Psychotic Disorder; diagnosis of Dementia
Recent hospitalization for suicidal ideation or suicide attempt; at hospital admission, Columbia Suicide Severity Rating Scale (CSSR-S) ≥ 2, "Non-specific Active Suicidal Thoughts."
We will also include patients on psychotropics and on after-care community psychotherapy.

Exclusion

Current diagnosis of Psychotic Disorders; Diagnosis of Dementia
Cognitive Impairment (MMSE ≤ 24)
Acute or severe medical illness (i.e., delirium; decompensated cardiac, liver or kidney failure; major surgery; stroke or myocardial infarction during the three months prior to entry
Aphasia, sensory problems, and/or inability to speak English.
  • Change in Event Related Potential - Late Positive Potential (ERP/LPP) - R61Study Entry, Week 6, Week 12

    ERP is used to measure the amplitude (magnitude) of electrocortical activity (measured in μV) during an emotion regulation task.

  • Change in Event Related Potential - Late Positive Potential (ERP/LPP) - R33Study Entry, Week 6, Week 12, Week 24

    ERP is used to measure the amplitude (magnitude) of electrocortical activity (measured in μV) during an emotion regulation task.

  • Change in Self-Reported Affect - R61Study Entry, Week 6, Week 12

    Self-reported affect is used to study changes in negative emotions during an EEG emotion regulation task. It is based on a participant's rating of negative emotions (Likert scale: 1-5; 5 most negative) during the task.

  • Change in Self-Reported Affect - R33Study Entry, Week 6, Week 12, Week 24

    Self-reported affect is used to study changes in negative emotions during an EEG emotion regulation task. It is based on a participant's rating of negative emotions (Likert scale: 1-5; 5 most negative) during the task.

  • Change in Emotion Regulation (Cognitive Reappraisal Subscale of ER Questionnaire) - R61Study Entry, Week 6, Week 12

    ERQ is an interviewer-administered instrument to evaluate cognitive reappraisal ability. Scores can range from 1-7, where higher scores indicate greater use of emotion regulation strategies and lower scores indicate less frequent use of such strategies.

  • Change in Emotion Regulation (Cognitive Reappraisal Subscale of ER Questionnaire) - R33Study Entry, Week 6, Week 12, Week 24

    ERQ is an interviewer-administered instrument to evaluate cognitive reappraisal ability. Scores can range from 1-7, where higher scores indicate greater use of emotion regulation strategies and lower scores indicate less frequent use of such strategies.

  • Change in Client Satisfaction with Treatment (CSQ) - R61Week 6, Week 12

    Client Satisfaction Questionnaire is a self-report that measures patient satisfaction with intervention/treatment. Scores can range from 3-12, where higher values indicate higher satisfaction.

  • Change in Client Satisfaction with Treatment (CSQ) - R33Week 6, Week 12, Week 24

    Client Satisfaction Questionnaire is a self-report that measures patient satisfaction with intervention/treatment. Scores can range from 3-12, where higher values indicate higher satisfaction.

  • Change in Suicide Risk - Columbia Suicide Severity Scale (C-SSRS) - R61Weekly from Study Entry to Week 12 (R61)

    C-SSRS is used to measure intensity of suicidal ideation. Scores range from 0-5, where higher scores indicate more severe ideation.

  • Change in Suicide Risk - Columbia Suicide Severity Scale (C-SSRS) - R33Weekly from Study Entry to Week 24

    C-SSRS is used to measure intensity of suicidal ideation. Scores range from 0-5, where higher scores indicate more severe ideation.