This study is looking at how the brain's cholinergic system, which is important for attention, learning, and memory, is affected in people with Down syndrome as they age and potentially develop Alzheimer's disease. Researchers will use a special imaging technique called a PET scan with an [18F]-FEOBV radiotracer (a substance that helps show specific things in the body during a scan) to measure changes in this system. The study aims to understand how these changes relate to the Basal Forebrain Cholinergic System Volume, which is a key area in the brain. They plan to enroll 30 participants between 18 and 55 years old who have a diagnosis of Down syndrome. The study's success will be measured by how well the PET scan results with the [18F]-FEOBV radiotracer correlate with the volume of this brain area. The current status of this study is unclear.

Study design

This is an interventional study planning to enroll 30 participants. The phase of the study is not specified.

What's involved

Participants will be given an [18F]-FEOBV radiotracer for diagnostic imaging using a PET scan. You will need to comply with all study procedures and be available for the duration of the study.

Compensation

Not stated in the trial record.

Follow-up

Analysis will be completed at study completion in approximately 3 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.