Written Exposure Therapy for Veterans with SUD and PTSD

This study is for Veterans who are dealing with both substance use disorders (SUD) and posttraumatic stress disorder (PTSD). It's testing if adding Written Exposure Therapy (WET) to their usual SUD treatment helps more than adding a neutral topic writing exercise. WET involves writing about a traumatic event in a specific way over five sessions. The study wants to see if WET can improve PTSD symptoms and addiction outcomes. To join, you must be a Veteran aged 18 or older, have both SUD and PTSD diagnoses, and be approved for SUD treatment at VA Connecticut Healthcare System. The study will measure success by looking at changes in PTSD symptoms using a special checklist at 8 and 12 weeks after treatment. The current status of this study is unclear.

Study design
This is a randomized clinical trial, meaning participants will be randomly assigned to one of two groups. It plans to enroll 170 Veterans.
What's involved
You would attend five writing sessions, either about a traumatic experience or a neutral topic. You would also have assessments at the start, after the writing sessions, and at 8 and 12 weeks later.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 12 weeks after their baseline assessment to check on their PTSD symptoms.

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NCT05327504

Written Exposure Therapy for Veterans With SUD and PTSD

Recruiting
NAAges 18+InterventionalTreatment
VA Office of Research and Development
~170 participants
Updated 2026-02-19 on ClinicalTrials.gov
What's tested:Written Exposure TherapyNeutral Topic Writing

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
PTSD Checklist for DSM-5 (PCL-5)
Measured over 8-week Post-Baseline Follow-up
+1 more outcome measured
Substance Use Disorders
Posttraumatic Stress Disorder
1 sites across 1 states
Connecticut1
  • Sarah Meshberg-Cohen, PhD MS BS · PRINCIPAL_INVESTIGATOR · VA Connecticut Healthcare System West Haven Campus, West Haven, CT

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Eligibility criteria

Inclusion

Veterans ages 18 years old or older;
Meets DSM-5 criteria for at least one substance use disorder (SUD);
Meets DSM-5 criteria for PTSD;
Approved for SUD treatment at VA Connecticut Healthcare System.

Exclusion

Veterans who meet current criteria for schizophrenia, schizophrenia-type disorders, or unmedicated mania or bipolar disorder as determined by QuickSCID-5;
current suicidal or homicidal risks necessitating a higher level of care;
Veterans who have received an Evidence-Based Psychotherapy for PTSD protocol within the past 6 months;
Problems that would prevent a participant from completing the writing intervention or study assessments (e.g., illiteracy). To assess for literacy, participants will read parts of the consent out loud.
  • PTSD Checklist for DSM-5 (PCL-5)8-week Post-Baseline Follow-up

    PTSD Checklist for DSM-5 (PCL-5) will be used to collect information on PTSD symptoms. The PCL-5 for DSM-5 is a 20-item self-report measure, selected for its dimensional sensitivity, with higher scores reflecting greater PTSD severity. Scoring is based on how much the patient has been bothered by the symptoms on a scale from "0 = not at all" to "4 = extremely." PCL scores will be collected based upon symptoms experienced in the past month at Baseline as well as each Post-Baseline Follow-up (8-weeks and 12-weeks), while the weekly PCL-5 will be administered at each of the five writing sessions and post-treatment (after 5 writing sessions) assessment. PCL-5 total symptom severity scores range from 0 to 80 with higher scores indicating greater PTSD severity.

  • PTSD Checklist for DSM-5 (PCL-5)12-week Post-Baseline Follow-up

    PTSD Checklist for DSM-5 (PCL-5) will be used to collect information on PTSD symptoms. The PCL-5 for DSM-5 is a 20-item self-report measure, selected for its dimensional sensitivity, with higher scores reflecting greater PTSD severity. Scoring is based on how much the patient has been bothered by the symptoms on a scale from "0 = not at all" to "4 = extremely." PCL scores will be collected based upon symptoms experienced in the past month at Baseline as well as each Post-Baseline Follow-up (8-weeks and 12-weeks), while the weekly PCL-5 will be administered at each of the five writing sessions and post-treatment (after 5 writing sessions) assessment. PCL-5 total symptom severity scores range from 0 to 80 with higher scores indicating greater PTSD severity.