{ "Understanding Depression in Adolescents: Inflammation and Brain Chemistry", "This observational study is looking for 160 adolescents aged 14-21 who are experiencing depression. The goal is to understand why some adolescents don't respond to common antidepressant medications like fluoxetine or escitalopram. You would participate in a mild stress test called the Trier Social Stress Test (TSST), which helps researchers look at how stress affects inflammation (your body's response to injury or infection) and glutamate (a brain chemical) levels. Researchers will measure your depression symptoms at the beginning of the study and again after 12 weeks to see if these stress-related factors can predict how well you respond to treatment. To join, you must be post-pubertal and not taking certain medications that could interfere with the study. The study's status is currently unclear.", "design": "This is an observational study, meaning researchers will observe participants without assigning them to different treatment groups. It aims to enroll 160 participants.", "commitments": "You would undergo a modified Trier Social Stress Test (TSST). Your depression symptoms will be measured at the start of the study and again after 12 weeks.", "compensation": "Not stated in the trial record.", "follow_up": "Your depression symptoms will be followed for 12 weeks after the start of the study, and your clinical course will be followed for 18 months.", }

Study design

Not specified.

What's involved

Not specified in the trial record.

Compensation

Not stated in the trial record.

Follow-up

Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.