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COMBAT-SI: Accelerated Theta Burst Stimulation for Suicidal Ideation in Depression

This study is testing a brain stimulation treatment called Accelerated Theta Burst Stimulation (aTBS) for people with treatment-resistant depression (TRD) and suicidal thoughts (suicidal ideation or SI). Researchers want to see if applying aTBS to both sides of the brain is more effective at reducing suicidal thoughts than applying it to only one side. You might be able to join if you are 18-70 years old, have been diagnosed with a major depressive episode, and have ongoing suicidal thoughts. The study will measure changes in your suicidal thoughts using a specific scale over 6 months to see how well the treatment works. The current recruitment status is unclear.

Study design
This is an interventional study with a planned enrollment of 76 participants, comparing two types of Accelerated Theta Burst Stimulation.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Changes in suicidal thoughts will be measured at 6 months after the start of the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05377177

Cortical Inhibition as a Biomarker of Response in a Comparison of Bilateral Versus Unilateral Accelerated Theta Burst Stimulation for Suicidal Ideation in Treatment-Resistant Depression -COMBAT-SI

Recruiting
NAAges 18–70InterventionalTreatment
University of California, San Diego
~76 participants
Updated 2025-11-05 on ClinicalTrials.gov
What's tested:Accelerated Theta Burst Stimulation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Changes in scores on the suicide scale index (SSI) from baseline
Measured over 6-months

Conditions

Suicidal Ideation
Treatment-resistant Depression

Explore related trials

DepressionSuicidal Ideation

NCT05377177

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • UCSD Interventional Psychiatry

    San Diego, Californiastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Interventional Psychiatry
[email protected]
(858) 657-6152
Email the study team

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What this trial measures

  • Changes in scores on the suicide scale index (SSI) from baseline6-months

    The primary outcome will be a comparison of change in score on the suicidality scale index (SSI) from baseline to endpoint of treatment between accelerated bilateral and unilateral treatment. The SSI contains 19 items scored from 0 to 2, higher scores indicating more severity, with overall scores ranging from 0 to 38The primary endpoint will be at treatment completion for both arms. The investigators will follow patients at 1, 2, 3, and 4 weeks post-treatment, as well as 3 and 6 months after treatment completion.