Study on Reward and Loss in Mood, Anhedonia, and Anxiety

This study is looking for 252 participants aged 25-50 who are experiencing depressed mood, anhedonia (loss of pleasure), or anxiety that affects their daily life. It aims to understand how people respond to rewards and losses, and if these responses are different for those with these conditions. You might receive cognitive behavioral therapy or participate in computerized learning games, either with or without instructions. The study will measure changes in your performance on a specific learning task over about 12 weeks to see if the interventions are successful. The current recruitment status is unclear.

Study design
This is an interventional study planning to enroll 252 participants. It is not specified if it is randomized or blinded.
What's involved
You would participate in repeat laboratory sessions involving a computerized learning game. The study will last an average of 12 weeks.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured from study entrance to study exit, an average of 12 weeks.

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NCT05384158

Valuation in Depressed Mood, Anhedonia, and Anxiety

Recruiting
NAAges 25–50InterventionalBasic science
Virginia Polytechnic Institute and State University
~252 participants
Updated 2026-08-28 on ClinicalTrials.gov
What's tested:cognitive behavioral therapyvaluation with instructionvaluation without instruction

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
change in proportion correct on the 'N-arm bandit learning task'
Measured over study entrance to study exit, an average of 12 weeks
Neurobehavioral Components of Reward and Loss Valuation
1 sites across 1 states
Virginia1

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Eligibility criteria

Inclusion

mood, anxiety, or anhedonia symptoms that affect functioning; fluent in English; able to see computer display; able to perform simple computer games.

Exclusion

history of seizure disorder, stroke, or head injury with more than 10 minutes of unconsciousness; hormone disorder; electroconvulsive therapy within 5 years; history of chemotherapy for cancer; current pregnancy; contraindications to MRI
  • change in proportion correct on the 'N-arm bandit learning task'study entrance to study exit, an average of 12 weeks

    change in proportion correct on 'N-arm bandit reinforcement learning task' from study entrance to study exit