Back to search results

Muscle Recovery After Critical Illness Study

This observational study is looking at how muscles recover after a critical illness, like sepsis or acute respiratory failure, that required a stay in the Intensive Care Unit (ICU). Researchers want to understand why some people recover their muscle strength and physical abilities, while others continue to experience weakness. They will follow participants over 12 months to measure changes in physical function, muscle power, and mitochondrial function (how cells produce energy). This study is for adult men who were admitted to the ICU for sepsis or acute respiratory failure for at least 72 hours and were able to walk before their ICU stay. The study is currently unclear about its recruitment status.

Study design
This is an observational study with a planned enrollment of 209 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 12 months to assess changes in physical function, mitochondrial function, and muscle power.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05537298

Muscle Recovery After Critical Illness

Recruiting
Not specifiedAges 18+Observational
Esther Dupont-Versteegden
~209 participants
Updated 2026-06-26 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Physical function
Measured over the change from baseline to 12-months
+2 more outcomes measured

Conditions

ICU Acquired Weakness
Post Intensive Care Unit Syndrome
Muscle Weakness
Critical Illness

Explore related trials

Critical IllnessICU Acquired WeaknessMuscle WeaknessPost intensive care unit syndrome

Where it's being run

3 sites across 3 states
Alabama1
Kentucky1
Oklahoma1

Study leadership

  • Kirby P Mayer, PhD · STUDY_DIRECTOR · University of Kentucky

Who to contact

Kirby P Mayer, PhD
[email protected]
859-218-0596
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

adult (\>18 y/o)
admission for sepsis or acute respiratory failure with at least 72 hour stay in ICU

Exclusion

patients who were not ambulatory prior to ICU admission
experienced \>2 ICU admissions in the past year (chronic or recurrent critical illness due to the same or different reason
patients not expected to survive \~6months after admission
acute or chronic neurologic condition
acute or chronic orthopedic condition preventing strength/functional testing
morbid obesity \>50 kg/m2 due to distortion of muscle ultrasonography

What this trial measures

  • Physical functionthe change from baseline to 12-months

    Short Physical Performance Battery

  • Mitochondrial functionthe change from baseline to 12-months

    muscle mitochondrial respirometry

  • Muscle powerthe change from baseline to 12-months

    lower-extremity muscle power (unilateral leg-press to record Watts)