Back to search results

RXWell for Mood Symptoms Before Knee or Hip Replacement

This study is testing if a digital behavioral health tool called RxWell can help reduce the amount of opioid pain medication people need after total knee or hip replacement surgery. RxWell uses techniques from Cognitive Behavioral Therapy (CBT) and includes guidance from a UPMC coach through an app. You might be able to join if you are an adult (18-100 years old) scheduled for elective total knee or hip replacement at a UPMC hospital and have moderately high levels of mood disorder symptoms (anxiety or depression). The study will measure how much opioid medication you use from the day after surgery up to four weeks later. The current recruitment status is unclear.

Study design
This is an interventional study with a planned enrollment of 150 participants. It compares receiving the RxWell app with a coach to usual care.
What's involved
If you receive RxWell, you will download an app and be paired with a UPMC coach who will guide you through sessions.
Compensation
Not stated in the trial record.
Follow-up
Your opioid consumption will be measured from the day after surgery up to four weeks post-operation.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05658796

RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty

Recruiting
NAAges 18+InterventionalPrevention
University of Pittsburgh
~150 participants
Updated 2026-06-03 on ClinicalTrials.gov
What's tested:+RxWell-RxWell

At a glance

Recruiting sites
3 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Cumulative Opioid Consumption in Oral Morphine Equivalent (OME) (mg)
Measured over POD 1 to Week 4 Post-Op

Conditions

Mood Disorders
Anxiety
Depressive Symptoms
Depression
Anxiety Disorders
Anxiety Depression

Explore related trials

Mood DisorderTotal Knee ReplacementTotal replacement of hip

Where it's being run

3 sites across 1 states
Pennsylvania3

Study leadership

  • Ata Murat Kaynar, MD, MPH · PRINCIPAL_INVESTIGATOR · UPMC Department of Anesthesiology and Perioperative Medicine

Who to contact

Ata Murat Kaynar, MD, MPH
[email protected]
412-383-3463
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Adults \>18 years
Scheduled for elective primary total knee arthroplasty (TKA) or hip replacement (THA) at the approved UPMC hospitals
Moderately high levels of mood disorder symptoms on validated PROMIS measures, defined as a T-score \> or = to 60 on PROMIS Anxiety 4a short form and/or PROMIS Depression4a short form

Exclusion

Patients undergoing non-elective surgery or secondary arthroplasty
Active delirium, neurocognitive impairment, or severe intellectual disability
No access to a smart device (phone or tablet)
Active alcoholism (defined as daily use of more than 1 liter of wine and /or 3 or more shots of hard liquor) or drug abuse (defined as daily use of illicit drugs)
Profound mood disorders requiring immediate intervention such as suicidal ideation, defined as a PROMIS Depression score of more than 70
A PROMIS Anxiety and/or Depression T-score \>70, which corresponds to severe anxiety and depression.
Patients needing immediate care will be referred to psychiatrists and primary team.

What this trial measures

  • Cumulative Opioid Consumption in Oral Morphine Equivalent (OME) (mg)POD 1 to Week 4 Post-Op

    This outcome will be measured by extracting pain medication data from the electronic health record to determine OME (oral morphine equivalents) (mg) for opioid medications on POD 1 and 2, and weeks 1 and 4 following surgery. This will be recorded for each study arm as mean (SD).