Total Knee Replacement clinical trials
57 active trials name this condition. Describe your situation to see which ones you may be eligible for.
By location
- Methadone in the Management of Post-Operative Pain in Total Knee Replacement
- Continuous Versus Single Injection Adductor Canal Blocks for Outpatient Total Knee Arthroplasty
- Mechanical Alignment vs Kalipered Kinematic Alignment Total Knee Arthroplasty
- Binaural Beats for Postoperative Pain and Anxiety Reduction
- Improving Total Knee Arthroplasty Dissatisfaction Through a Personalized Approach Focusing on PROMs Phenotypes
- Implementation of Neuromuscular Electrical Stimulation After Total Knee Arthroplasty
- Intraosseous (IO) Cefazolin and Vancomycin in Primary Total Knee Arthroplasty (TKA)
- Effects of tDCS Combined With CBI on Postsurgical Pain
- REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee Arthroplasty in Adults
- REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee Arthroplasty in Adult Participants
- Effectiveness of Exparel Anesthetic Administered by the Surgeon During Knee Surgery
- Investigating Patient Satisfaction With Smart Knee Implants
- Brain-Computer Interface Visualization Training to Optimize Muscle Activation Following Orthopaedic Surgery
- Optimizing a Remote-based Physical Activity Intervention for Adults with Total Knee Replacement
- A Prospective, Single-arm, Trial to Determine Contamination Rates When Using an Antibacterial Incise Drape During Orthopedic Surgery
- A Prospective, Randomized Parallel Group Study of the Efficacy of Vancomycin Administered Through Intraarticular Injection Versus Intraosseous Injection Versus Intravenous Infusion in Patients Undergoing Total Knee Arthroplasty
- Optimal Dosing For Low-Dose Aspirin Chemoprophylaxis For VTE Following Total Joint Arthroplasty
- Preoperative Oral Hydration in the Ambulatory Arthroplasty Population
- Pre-operative Inspiratory Muscle Strength Training in Total Joint Surgery
- RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty
- Feasibility of Breathwork Intervention With Older Adults After Knee Surgery
- Mako-MORE Registry
- An Open Label Data Collection Study of My Connect Post-Op, a Post-Operative Communication Tool
- Evaluation of Outcomes of the Triathlon Hinge Knee (THK) System
- A Post-Market Domestic (US) and International Data Collection to Assess the Truliant Knee System
- Improving Rehabilitation for Veterans After Total Knee Arthroplasty Using Individualized Recovery Trajectories
- Diaphragmatic Breathing Exercises in Total Knee Arthroplasty Patients
- HealthEast Community Hip and Knee Replacement Registry
- Total Intravenous Anesthesia vs Spinal Anesthesia in Patients Undergoing Unilateral Primary Total Knee Arthroplasty
- Is Physical Therapy Clearance Before Arthroplasty Home Discharge Necessary?
- Femoral BMD Change Following Cemented or Cementless Total Knee Arthroplasty
- Observation of Wheeled Device Use After TKA
- A Comparison Of Primary TKA Rehabilitation Using A Smart Orthotic Versus Outpatient Physical Therapy
- Minimal Sedation During Knee Replacement Surgery
- NEUROCUPLE™ as an Opioid Alternative Following Total Knee Arthroplasty
- Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canalf and iPACK Blocks in Total Knee Arthroplasty
- Veterans Enhanced Recovery Using Integrative Treatments Around Surgery
- Using a Smart Implantable Device to Compare Early Recovery in Two Different Knee Arthroplasty Approaches
- The Feasibility of a Nurse-Initiated Weighted Blanket in Orthopedic Surgical Patients Undergoing Total Knee Arthroplasty
- Utilization of a 3D Printed Mechanical Balancer During Total Knee Arthroplasty (TKA)
- Aprepitant to Improve Same Day Discharge for TKA
- IO Vancomycin Administration in TKA
- Doxepin Alone or Combined With Ramelteon Versus Placebo for Improving Sleep Quality After Primary Total Knee Arthroplasty
- Knee Replacement Rehabilitation Care Pathways
- Extended Oral Tranexamic Acid After Primary Total Knee Arthroplasty
- A Study of the Effect of a Nurse Navigator Program on High Risk Patients
- Metal Ion Concentrations After Total Knee Arthroplasty
- Genetic Susceptibility to Periprosthetic Joint Infections
- A Study to Evaluate Virtual Reality As Adjunct to Anesthesia During Orthopedic Surgery
- Pilot Study on EXPAREL as an Intra-articular Posteromedial Surgeon Administered (IPSA) Block vs. Local Infiltration Analgesia in Knee Replacement Surgery
Guides for people searching for a trial
- Why people get turned down — and what to do nextWhat eligibility criteria are for, what keeps people out, and where to go when the first door closes.
- How your biomarkers decide which trials you qualify forEGFR, HER2, BRAF, PD-L1 and the rest — what they are and why they increasingly gate access.
- How to search for a trial without losing your mindWhere to look, what to gather first, and how to read what you find.
- What Phase 1, 2 and 3 actually mean for youWhat each phase is testing, and how to weigh an early-phase trial against a later one.
- 10 questions to ask before you say yesTreatment, time, cost, safety and your rights. Worth bringing to a screening visit.
- You matched with a trial. What happens now?Phone screens, the screening visit, informed consent, and day one.
Showing active trials that list “Total Knee Replacement” as a condition. Eligibility shown on each trial is an estimate — the trial's study team makes the final decision.