REGN7508 for Preventing Blood Clots After Knee Replacement

This study is testing an experimental drug called REGN7508 against a common treatment, Acetylsalicylic Acid (ASA), also known as aspirin. The goal is to see how well REGN7508 prevents blood clots (Venous Thromboembolism or VTE) and other related health issues after total knee replacement surgery. You might be able to join if you are an adult having elective, single-side total knee replacement surgery and are in good health. The main way we'll know if the study is successful is by looking at how many people experience VTE or death from any cause up to 30 days after their surgery. This study is currently recruiting about 2000 participants.

Study design
This is an interventional study comparing REGN7508, Acetylsalicylic Acid (ASA), and a placebo. It plans to enroll 2000 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed through a 30-day visit after their surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07213778

REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee Arthroplasty in Adult Participants

Recruiting
PHASE3Ages 18+InterventionalTreatment
Regeneron Pharmaceuticals
~2,000 participants
Updated 2026-08-19 on ClinicalTrials.gov
What's tested:REGN7508Acetylsalicylic Acid (ASA)Placebo

At a glance

Recruiting sites
33 of 34 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Incidence of the composite endpoint of symptomatic VTE and all-cause death
Measured over Through day 30 visit
Symptomatic Venous Thromboembolism (VTE)
34 sites across 21 states
Florida4
Texas4
North Carolina3
Ohio3
California2
Maryland2
Massachusetts2
Colorado1
  • Clinical Trial Management · STUDY_DIRECTOR · Regeneron Pharmaceuticals

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  • Incidence of the composite endpoint of symptomatic VTE and all-cause deathThrough day 30 visit