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Anesthesia Options for Total Knee Replacement Surgery

This study is comparing two types of anesthesia for adults having total knee replacement (arthroplasty) surgery: Total Intravenous Anesthesia (TIVA) using medicines like propofol and fentanyl, or a Spinal Block using mepivacaine. The main goal is to see if one type of anesthesia helps more people go home the same day as their surgery. Researchers will also look at how you recover in the hospital, including pain, nausea, and how well you think. You might be able to join if you are 18 or older, having a total knee replacement at the University of Chicago, and are already considered eligible to go home the same day after surgery. The current status of this study is unclear.

Study design
This study is comparing two different anesthesia methods in 150 participants. Participants will be randomly assigned to receive either Total Intravenous Anesthesia or a Spinal Block.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome of same-day discharge rates is measured on PostOperative Day-0.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07672301

Total Intravenous Anesthesia vs Spinal Anesthesia in Patients Undergoing Unilateral Primary Total Knee Arthroplasty

Recruiting
PHASE1Ages 18+Interventional
University of Chicago
~150 participants
Updated 2026-06-26 on ClinicalTrials.gov
What's tested:Total IntraVenous Anesthesia (TIVA)Spinal-BlockElectroencephalogram (EEG)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Compare Same-Day Discharge (SDD) Rates
Measured over at PostOperative (Day-0)

Conditions

Total Knee Arthroplasty (TKA)

Explore related trials

Total Knee Replacement

Where it's being run

1 sites across 1 states
Illinois1

Study leadership

  • Zheng Xie, MD, PhD · PRINCIPAL_INVESTIGATOR · University of Chicago, Department of Anesthesia and Critical Care

Who to contact

Frank T Brown Jr, MA
[email protected]
773-834-5778
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Adults aged ≥18 years.
Scheduled to undergo elective primary total knee arthroplasty (TKA) or robotic total knee arthroplasty (TKA) at the University of Chicago.
Eligible for same-day discharge (SDD) based on established orthopedic and anesthesia criteria.
Able to provide written informed consent.
The ability to comprehend and complete cognitive assessment surveys and questionnaires.
Consent to receive either Total IntraVenous Anesthesia (TIVA) or Spinal-block Anesthesia in a randomized manner
No contraindication to either TIVA or spinal anesthesia

Exclusion

Age \<18 years.
Patients undergoing revision TKA or procedures other than elective primary TKA.
Ineligibility for same-day discharge as determined by the surgical or anesthesia team.
Contraindications to either anesthetic technique (e.g., spinal block anesthesia contraindicated due to coagulopathy, infection at puncture site, or patient refusal).
Known allergy or hypersensitivity to study-related medications.
Significant pre-existing cognitive impairment or dementia that would preclude valid participation in Short Portable Mental Status Questionnaire (SPMSQ), and 3-Minute Diagnostic Assessment for Confusion Assessment Method (3D-CAM) assessments.
Severe chronic pain syndromes (e.g., fibromyalgia, centrally mediated pain disorders) that could confound perioperative pain assessment.
Body mass index (BMI) \> 40.
Prisoners or other vulnerable populations unable to provide voluntary consent.
Unable to give appropriate consent or difficult to comprehend and complete cognitive assessment surveys and questionnaires

What this trial measures

  • Compare Same-Day Discharge (SDD) Ratesat PostOperative (Day-0)

    Comparison of same-day discharge rates between patients receiving either total intravenous anesthesia (TIVA) or spinal-block anesthesia, during total knee arthroplasty (TKA).