Back to search results

Optimizing a Remote Physical Activity Program After Knee Replacement

This study aims to improve physical activity levels in adults who have had a total knee replacement. You'll participate in an online exercise program called 'MOST Energized!' and may also receive phone coaching, monthly 'Hear from Others' videos, and individualized feedback via email. The researchers want to see which of these additional supports best helps people increase their physical activity (how many minutes per week they exercise) and meet physical activity guidelines. They will measure these changes at 6 and 12 months. To join, you must have had a knee replacement at least 12 months ago, use a computer or smartphone with internet, and currently exercise less than 60 minutes per week. The study plans to enroll 336 participants, but its current status is unclear.

Study design
This study is an interventional study with a planned enrollment of 336 participants. It aims to identify which additional components best support an online exercise program.
What's involved
You will receive an online exercise program for 6 months. This includes weekly video lessons for the first three months, then monthly, and 'Apply Your Knowledge' activities. You may also have weekly or monthly phone calls with a health coach and receive email feedback.
Compensation
Not stated in the trial record.
Follow-up
Your physical activity will be measured at 6 and 12 months after starting the program.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06768762

Optimizing a Remote-based Physical Activity Intervention for Adults With Total Knee Replacement

Recruiting
NAAges 18+InterventionalPrevention
University of South Carolina
~336 participants
Updated 2026-05-05 on ClinicalTrials.gov
What's tested:Phone CoachingProgress reports to providers'Hear from Others' VideosIndividualized FeedbackOnline exercise program

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Physical activity (min/week)
Measured over Baseline to 6 months
+3 more outcomes measured

Conditions

Knee Replacement

Explore related trials

Total Knee Replacement

Where it's being run

1 sites across 1 states
South Carolina1

Study leadership

  • Christine Pellegrini, PhD · PRINCIPAL_INVESTIGATOR · University of South Carolina
  • Jessica Unick, PhD · PRINCIPAL_INVESTIGATOR · The Miriam Hospital

Who to contact

Jakob Nelson, MS
[email protected]
803-766-6960
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

had a knee replacement (including primary, staged or independent bilateral, or revision) at least 12 months ago
have a computer, tablet, or smartphone with active internet access
self-report engaging in less than 60 minutes/week of moderate-intensity physical activity
be English-speaking and able to read consent and study materials written in English
be willing to complete the 4 remote assessments, including physical activity monitoring
be willing to be randomized to receive 0-4 supplemental intervention components.

Exclusion

any contraindications to physical activity (e.g., chest pain)
have a scheduled surgery within the next 12 months (e.g., hip or knee replacement)
have a mobility limiting comorbidity unrelated to knee replacement
live outside of the continental U.S
do not currently have a physician or orthopedic surgeon whom they see regularly
are currently participating in physical therapy (for knee)
are participating in a structured weight loss or physical activity program
unable to provide proof of knee replacement surgery
have a BMI \>40kg/m2
score \>30 on PROMIS cognitive function

What this trial measures

  • Physical activity (min/week)Baseline to 6 months

    Change in Actigraph-assessed moderate-to-vigorous intensity physical activity

  • Percentage meeting physical activity guidelines6 months

    Percentage of participants meeting physical activity guidelines (150 minutes/week)

  • Physical activity (min/week)Baseline to 12 months

    Change in Actigraph-assessed moderate-to-vigorous intensity physical activity

  • Percentage meeting physical activity guidelines12 months

    Percentage of participants meeting physical activity guidelines (150 minutes/week)