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Neuromuscular Electrical Stimulation After Total Knee Arthroplasty

This study is looking at how well Neuromuscular Electrical Stimulation (NMES) works after total knee replacement surgery. NMES uses electrical pulses to help strengthen muscles. After knee replacement, many people experience weakness in their thigh muscles (quadriceps), which can make recovery harder. This study aims to see if using NMES more often in physical therapy can help improve your strength and ability to move. You might be able to join if you are 18 or older, recently had a single knee replacement, and are attending physical therapy at a UCHealth or Intermountain Health clinic. The main way success will be measured is by how quickly you can complete a "Timed Up and Go" test, which measures how fast you can stand up, walk a short distance, and sit back down. The current status of this study is unclear.

Study design
This is an interventional study planning to enroll 3250 participants. It compares Neuromuscular Electrical Stimulation (NMES) to usual care.
What's involved
You would attend outpatient physical therapy visits for up to 24 weeks, where NMES may be applied. Your physical performance outcomes will be regularly documented.
Compensation
Not stated in the trial record.
Follow-up
Your progress will be followed for up to 24 weeks after your surgery, with measurements taken at several points during this time.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06953375

Implementation of Neuromuscular Electrical Stimulation After Total Knee Arthroplasty

Recruiting
NAAges 18+InterventionalTreatment
University of Colorado, Denver
~3,250 participants
Updated 2025-09-29 on ClinicalTrials.gov
What's tested:NMESUsual Care

At a glance

Recruiting sites
3 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Timed Up and Go (TUG)
Measured over Pre-operative visit; Post-operative PT baseline, 2 weeks, 4 weeks (primary endpoint), 6 weeks, up to 24 weeks

Conditions

Total Knee Arthroplasty
Functional Recovery
Aging
Physical Therapy

Explore related trials

Total Knee Replacement

Where it's being run

3 sites across 2 states
Colorado2
Utah1

Study leadership

  • Jennifer Stevens-Lapsley, PT, PhD · PRINCIPAL_INVESTIGATOR · University of Colorado, Denver

Who to contact

Maggie Givan, MA
[email protected]
719.251.7533
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Underwent primary unilateral TKA
Attended outpatient rehabilitation at a participating clinic within 5 days after TKA
Attended at least 3 total outpatient physical therapy visits in total

Exclusion

NMES Contraindications \[Patients with implanted cardiovascular cardiovertedefibrillator (ICD), active cancer, post-operative diagnosed deep vein thrombosis (DVT) in involved lower extremity\]
Previous lower extremity arthroplasty less than 12 weeks prior to scheduled TKA surgical date

What this trial measures

  • Timed Up and Go (TUG)Pre-operative visit; Post-operative PT baseline, 2 weeks, 4 weeks (primary endpoint), 6 weeks, up to 24 weeks

    The TUG is a measure of mobility and balance that consists of rising from a seated position, walking three meters, and pivoting and returning to the original seated position. Faster times indicate better physical function.