This study is looking at whether a single dose of methadone given intravenously (into a vein) right before total knee replacement surgery can help manage pain and reduce the amount of other pain medications you need in the weeks after surgery. You might be able to join if you are between 21 and 75 years old and are having a total knee replacement at Colorado Joint Replacement. The study will consider it a success if patients use less pain medication in the 48 hours after their surgery. The current recruitment status for this study is unclear.

Study design

This is an interventional study planning to enroll 192 participants. Participants will be randomly assigned to receive methadone or not.

What's involved

You would need to be willing to follow all study procedures and attend all required visits for the duration of the study. One dose of methadone would be given before your surgery.

Compensation

Not stated in the trial record.

Follow-up

The study will track your opioid use for 48 hours after your total knee replacement procedure.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.