Metal Ion Concentrations After Total Knee Arthroplasty

This study is looking at the levels of certain metals (Cobalt, Chromium, Titanium, and Nickel) in your blood after you have a total knee replacement (TKA). Researchers want to see if there are differences in these metal levels between people who have a traditional TKA using cutting guides and those who have a robotic-assisted TKA. You can join if you are an adult between 18 and 100 years old, are having your first knee replacement, and do not have other metal implants in your body or weigh less than 110 pounds. The study will consider itself successful if it finds differences in metal ion levels between the two types of knee replacement procedures. The current status of this study is unclear.

Study design
This is an observational study involving 60 participants. It compares two groups: those having conventional total knee replacement and those having robotic-assisted total knee replacement.
What's involved
You would have a blood draw before your surgery and another on the first day after your surgery to check metal ion levels.
Compensation
Not stated in the trial record.
Follow-up
Your metal ion levels will be measured pre-operatively and on the first post-operative day.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06447922

Metal Ion Concentrations After Total Knee Arthroplasty

Enrolling by Invitation
Not specifiedAges 18+Observational
Mayo Clinic
~60 participants
Updated 2026-07-13 on ClinicalTrials.gov
What's tested:Metal ion level testing

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Overall blood metal ion differences between procedures (Conventional TKA vs Robot-Assisted TKA)
Measured over Pre-operatively, first post-operative day.
Arthroplasty, Replacement, Knee
Total Knee Replacement
Blood Metal Ion Concentration
1 sites across 1 states
Minnesota1
  • Matthew P Abdel · PRINCIPAL_INVESTIGATOR · Mayo Clinic

This trial hasn't published a contact. View it on ClinicalTrials.gov

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Eligibility criteria

Inclusion

Adults undergoing conventional or robotic-assisted TKA
Consent to the study

Exclusion

Patients who have undergone any previous arthroplasty procedures.
Patients with metal implants, such as plates, nails, and screws, used in the repair of traumatic injuries.
Patients below 110 pounds.
  • Overall blood metal ion differences between procedures (Conventional TKA vs Robot-Assisted TKA)Pre-operatively, first post-operative day.

    Difference in overall blood metal ion levels (Cobalt, Chromium, Titanium, and Nickel) between patients undergoing total knee arthroplasty (TKA) with conventional cutting guides and those undergoing TKA with robotic assistance.